Extranodal NKT-Cell Lymphoma : Toward the Identification of Clinical Molecular Targets
Joint Authors
Huang, Yenlin
Bensussan, Armand
Bagot, Martine
Schmitt, Christian
Sako, Nouhoum
Gaulard, Philippe
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-20
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Extranodal natural killer (NK)/T-cell lymphoma of nasal type (NKTCL) is a malignant disorder of cytotoxic lymphocytes of NK or more rarely T cells associated with clonal Epstein-Barr virus infection.
Extranodal NKTCL is rare in Western countries, but in Asia and Central and South America it can account for up to 10% of non-Hodgkin's lymphomas.
It is an aggressive neoplasm with very poor prognosis.
Although the pathogenesis of extranodal NKTCL remains poorly understood, some insights have been gained in the recent years, especially from genome-wide studies.
Based on our own experience and knowledge of the literature, we here review some of the genomic and functional pathway alterations observed in NKTCL that could provide a rationale for the development of innovative therapeutic strategies.
American Psychological Association (APA)
Schmitt, Christian& Sako, Nouhoum& Bagot, Martine& Huang, Yenlin& Gaulard, Philippe& Bensussan, Armand. 2011. Extranodal NKT-Cell Lymphoma : Toward the Identification of Clinical Molecular Targets. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-498344
Modern Language Association (MLA)
Schmitt, Christian…[et al.]. Extranodal NKT-Cell Lymphoma : Toward the Identification of Clinical Molecular Targets. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-498344
American Medical Association (AMA)
Schmitt, Christian& Sako, Nouhoum& Bagot, Martine& Huang, Yenlin& Gaulard, Philippe& Bensussan, Armand. Extranodal NKT-Cell Lymphoma : Toward the Identification of Clinical Molecular Targets. Journal of Biomedicine and Biotechnology. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-498344
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-498344