Liver Resection after Downstaging Hepatocellular Carcinoma with Sorafenib
Joint Authors
Le Guellec, S.
Suc, B.
Pariente, Alexandre
Otal, Phillippe
Barbier, L.
Muscari, F.
Source
International Journal of Hepatology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-20
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
Sorafenib is a molecular-targeted therapy used in palliative treatment of advanced hepatocellular carcinoma in Child A patients.
Aims.
To address the question of sorafenib as neoadjuvant treatment.
Methods.
We describe the cases of 2 patients who had surgery after sorafenib.
Results.
The patients had a large hepatocellular carcinoma in the right liver with venous neoplastic thrombi (1 in the right portal branch, 1 in the right hepatic vein).
After 9 months of sorafenib, reassessment showed that tumours had decreased in size with a necrotic component.
A right hepatectomy with thrombectomy was performed, and histopathology showed 35% to 60% necrosis.
One patient had a recurrence after 6 months and had another liver resection; they are both recurrence-free since then.
Conclusion.
Sorafenib can downstage hepatocellular carcinoma and thus could represent a bridge to surgery.
It may be possible to select patients in good general condition with partial regression of the tumour with sorafenib for a treatment in a curative intent.
American Psychological Association (APA)
Barbier, L.& Muscari, F.& Le Guellec, S.& Pariente, Alexandre& Otal, Phillippe& Suc, B.. 2011. Liver Resection after Downstaging Hepatocellular Carcinoma with Sorafenib. International Journal of Hepatology،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-498356
Modern Language Association (MLA)
Barbier, L.…[et al.]. Liver Resection after Downstaging Hepatocellular Carcinoma with Sorafenib. International Journal of Hepatology No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-498356
American Medical Association (AMA)
Barbier, L.& Muscari, F.& Le Guellec, S.& Pariente, Alexandre& Otal, Phillippe& Suc, B.. Liver Resection after Downstaging Hepatocellular Carcinoma with Sorafenib. International Journal of Hepatology. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-498356
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-498356