Update on a Pharmacokinetic-Centric Alternative Tier II Program for MMT—Part II : Physiologically Based Pharmacokinetic Modeling and Manganese Risk Assessment
Joint Authors
Taylor, Michael D.
Clewell, Harvey J.
Andersen, Melvin E.
Keene, Athena M.
Schroeter, Jeffry D.
Dorman, David C.
Yoon, Miyoung
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-07
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Pharmacy, Health & Medical Sciences
Medicine
Abstract EN
Recently, a variety of physiologically based pharmacokinetic (PBPK) models have been developed for the essential element manganese.
This paper reviews the development of PBPK models (e.g., adult, pregnant, lactating, and neonatal rats, nonhuman primates, and adult, pregnant, lactating, and neonatal humans) and relevant risk assessment applications.
Each PBPK model incorporates critical features including dose-dependent saturable tissue capacities and asymmetrical diffusional flux of manganese into brain and other tissues.
Varied influx and efflux diffusion rate and binding constants for different brain regions account for the differential increases in regional brain manganese concentrations observed experimentally.
We also present novel PBPK simulations to predict manganese tissue concentrations in fetal, neonatal, pregnant, or aged individuals, as well as individuals with liver disease or chronic manganese inhalation.
The results of these simulations could help guide risk assessors in the application of uncertainty factors as they establish exposure guidelines for the general public or workers.
American Psychological Association (APA)
Taylor, Michael D.& Clewell, Harvey J.& Andersen, Melvin E.& Schroeter, Jeffry D.& Yoon, Miyoung& Keene, Athena M.…[et al.]. 2012. Update on a Pharmacokinetic-Centric Alternative Tier II Program for MMT—Part II : Physiologically Based Pharmacokinetic Modeling and Manganese Risk Assessment. Journal of Toxicology،Vol. 2012, no. 2012, pp.1-17.
https://search.emarefa.net/detail/BIM-498397
Modern Language Association (MLA)
Taylor, Michael D.…[et al.]. Update on a Pharmacokinetic-Centric Alternative Tier II Program for MMT—Part II : Physiologically Based Pharmacokinetic Modeling and Manganese Risk Assessment. Journal of Toxicology No. 2012 (2012), pp.1-17.
https://search.emarefa.net/detail/BIM-498397
American Medical Association (AMA)
Taylor, Michael D.& Clewell, Harvey J.& Andersen, Melvin E.& Schroeter, Jeffry D.& Yoon, Miyoung& Keene, Athena M.…[et al.]. Update on a Pharmacokinetic-Centric Alternative Tier II Program for MMT—Part II : Physiologically Based Pharmacokinetic Modeling and Manganese Risk Assessment. Journal of Toxicology. 2012. Vol. 2012, no. 2012, pp.1-17.
https://search.emarefa.net/detail/BIM-498397
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-498397