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Generation and Characterization of Erythroid Cells from Human Embryonic Stem Cells and Induced Pluripotent Stem Cells : An Overview
Joint Authors
Chang, Kai-Hsin
Papayannopoulou, Thalia
Bonig, Halvard
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-26
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
Because of the imbalance in the supply and demand of red blood cells (RBCs), especially for alloimmunized patients or patients with rare blood phenotypes, extensive research has been done to generate therapeutic quantities of mature RBCs from hematopoietic stem cells of various sources, such as bone marrow, peripheral blood, and cord blood.
Since human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) can be maintained indefinitely in vitro, they represent potentially inexhaustible sources of donor-free RBCs.
In contrast to other ex vivo stem-cell-derived cellular therapeutics, tumorigenesis is not a concern, as RBCs can be irradiated without marked adverse effects on in vivo function.
Here, we provide a comprehensive review of the recent publications relevant to the generation and characterization of hESC- and iPSC-derived erythroid cells and discuss challenges to be met before the eventual realization of clinical usage of these cells.
American Psychological Association (APA)
Chang, Kai-Hsin& Bonig, Halvard& Papayannopoulou, Thalia. 2011. Generation and Characterization of Erythroid Cells from Human Embryonic Stem Cells and Induced Pluripotent Stem Cells : An Overview. Stem Cells International،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-498411
Modern Language Association (MLA)
Chang, Kai-Hsin…[et al.]. Generation and Characterization of Erythroid Cells from Human Embryonic Stem Cells and Induced Pluripotent Stem Cells : An Overview. Stem Cells International No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-498411
American Medical Association (AMA)
Chang, Kai-Hsin& Bonig, Halvard& Papayannopoulou, Thalia. Generation and Characterization of Erythroid Cells from Human Embryonic Stem Cells and Induced Pluripotent Stem Cells : An Overview. Stem Cells International. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-498411
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-498411