Roles of Mucosal Immunity against Mycobacterium tuberculosis Infection
Joint Authors
Li, Wu
Wang, Yujiong
Li, Min
Deng, Guangcun
Liu, Xiaoming
Source
Tuberculosis Research and Treatment
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-01
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), is one of the world's leading infectious causes of morbidity and mortality.
As a mucosal-transmitted pathogen, Mtb infects humans and animals mainly through the mucosal tissue of the respiratory tract.
Apart from providing a physical barrier against the invasion of pathogen, the major function of the respiratory mucosa may be to serve as the inductive sites to initiate mucosal immune responses and sequentially provide the first line of defense for the host to defend against this pathogen.
A large body of studies in the animals and humans have demonstrated that the mucosal immune system, rather than the systemic immune system, plays fundamental roles in the host’s defense against Mtb infection.
Therefore, the development of new vaccines and novel delivery routes capable of directly inducing respiratory mucosal immunity is emphasized for achieving enhanced protection from Mtb infection.
In this paper, we outline the current state of knowledge regarding the mucosal immunity against Mtb infection, including the development of TB vaccines, and respiratory delivery routes to enhance mucosal immunity are discussed.
American Psychological Association (APA)
Li, Wu& Deng, Guangcun& Li, Min& Liu, Xiaoming& Wang, Yujiong. 2012. Roles of Mucosal Immunity against Mycobacterium tuberculosis Infection. Tuberculosis Research and Treatment،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-498428
Modern Language Association (MLA)
Li, Wu…[et al.]. Roles of Mucosal Immunity against Mycobacterium tuberculosis Infection. Tuberculosis Research and Treatment No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-498428
American Medical Association (AMA)
Li, Wu& Deng, Guangcun& Li, Min& Liu, Xiaoming& Wang, Yujiong. Roles of Mucosal Immunity against Mycobacterium tuberculosis Infection. Tuberculosis Research and Treatment. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-498428
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-498428