Functionally Defective High-Density Lipoprotein and Paraoxonase : A Couple for Endothelial Dysfunction in Atherosclerosis
Joint Authors
Eren, Esin
Aydin, Ozgur
Yilmaz, Necat
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-07
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The endothelium is the primary target for biochemical or mechanical injuries caused by the putative risk factors of atherosclerosis.
Endothelial dysfunction represents the ultimate link between atherosclerotic risk factors that promote atherosclerosis.
HDL-C is thought to exert at least some parts of its antiatherogenic facilities via stimulating endothelial NO production, nearby inhibiting oxidative stress and inflammation.
HDL-C is capable of opposing LDL’s inductive effects and avoiding the ox-LDL’s inhibition of eNOS.
Paraoxonase 1 (PON1) is an HDL-associated enzyme esterase which appears to contribute to the antioxidant and antiatherosclerotic capabilities of HDL-C.
“Healthy HDL,” namely the particle that contains the active Paraoxonase 1, has the power to suppress the formation of oxidized lipids.
“Dysfunctional HDL,” on the contrary, has reduced Paraoxonase 1 enzyme activity and not only fails in its mission but also potentially leads to greater formation of oxidized lipids/lipoproteins to cause endothelial dysfunction.
The association of HDL-C PON1 and endothelial dysfunction depends largely on the molecules with exact damaging effect on NO synthase coupling.
Loss of nitric oxide bioavailability has a pivotal role in endothelial dysfunction preceding the appearance of atherosclerosis.
Analyses of HDL-C and Paraoxonase1 would be more important in the diagnosis and treatment of atherosclerosis in the very near future.
American Psychological Association (APA)
Eren, Esin& Yilmaz, Necat& Aydin, Ozgur. 2013. Functionally Defective High-Density Lipoprotein and Paraoxonase : A Couple for Endothelial Dysfunction in Atherosclerosis. Cholesterol،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-498463
Modern Language Association (MLA)
Eren, Esin…[et al.]. Functionally Defective High-Density Lipoprotein and Paraoxonase : A Couple for Endothelial Dysfunction in Atherosclerosis. Cholesterol No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-498463
American Medical Association (AMA)
Eren, Esin& Yilmaz, Necat& Aydin, Ozgur. Functionally Defective High-Density Lipoprotein and Paraoxonase : A Couple for Endothelial Dysfunction in Atherosclerosis. Cholesterol. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-498463
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-498463