The Autoimmune Tautology : An In Silico Approach
Joint Authors
Anaya, Juan-Manuel
Restrepo-Montoya, Daniel
Cifuentes, Ricardo A.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-05
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
There is genetic evidence of similarities and differences among autoimmune diseases (AIDs) that warrants looking at a general panorama of what has been published.
Thus, our aim was to determine the main shared genes and to what extent they contribute to building clusters of AIDs.
We combined a text-mining approach to build clusters of genetic concept profiles (GCPs) from the literature in MedLine with knowledge of protein-protein interactions to confirm if genes in GCP encode proteins that truly interact.
We found three clusters in which the genes with the highest contribution encoded proteins that showed strong and specific interactions.
After projecting the AIDs on a plane, two clusters could be discerned: Sjögren’s syndrome—systemic lupus erythematosus, and autoimmune thyroid disease—type1 diabetes—rheumatoid arthritis.
Our results support the common origin of AIDs and the role of genes involved in apoptosis such as CTLA4, FASLG, and IL10.
American Psychological Association (APA)
Cifuentes, Ricardo A.& Restrepo-Montoya, Daniel& Anaya, Juan-Manuel. 2012. The Autoimmune Tautology : An In Silico Approach. Autoimmune Diseases،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-498464
Modern Language Association (MLA)
Cifuentes, Ricardo A.…[et al.]. The Autoimmune Tautology : An In Silico Approach. Autoimmune Diseases No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-498464
American Medical Association (AMA)
Cifuentes, Ricardo A.& Restrepo-Montoya, Daniel& Anaya, Juan-Manuel. The Autoimmune Tautology : An In Silico Approach. Autoimmune Diseases. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-498464
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-498464