Use of the Charge Transfer Reactions for the Spectrophotometric Determination of Risperidone in Pure and in Dosage Forms
Joint Authors
Revanasiddappa, Hosakere Doddarevanna
Deepakumari, Hemavathi Nagaraju
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-26
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Pharmacy, Health & Medical Sciences
Economics & Business Administration
Pharmacology
Abstract EN
The aim of study was to develop and validate two simple, sensitive, and extraction-free spectrophotometric methods for the estimation of risperidone in both pure and pharmaceutical preparations.
They are based on the charge transfer complexation reactions between risperidone (RSP) as n-electron donor and p-chloranilic acid (p-CA) in method A and 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) in method B as π-acceptors.
In method A, RSP reacts with p-CA in methanol to produce a bright pink-colored chromogen measured at 530 nm whereas, in method B, RSP reacts with DDQ in dichloromethane to form orange-colored complex with a maximum absorption at 460 nm.
Beer's law was obeyed in the concentration range of 0–25 and 0–50 μg/mL with molar absorptivity of 1.29×104 and 0.48×104 L/moL/cm for RSP in methods A and B, respectively.
The effects of variables such as reagents, time, and stability of the charge transfer complexes were investigated to optimize the procedures.
The proposed methods have been successfully applied to the determination of RSP in pharmaceutical formulations.
Results indicate that the methods are accurate, precise, and reproducible (relative standard deviation <2 %).
American Psychological Association (APA)
Deepakumari, Hemavathi Nagaraju& Revanasiddappa, Hosakere Doddarevanna. 2012. Use of the Charge Transfer Reactions for the Spectrophotometric Determination of Risperidone in Pure and in Dosage Forms. Journal of Pharmaceutics،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-498474
Modern Language Association (MLA)
Deepakumari, Hemavathi Nagaraju& Revanasiddappa, Hosakere Doddarevanna. Use of the Charge Transfer Reactions for the Spectrophotometric Determination of Risperidone in Pure and in Dosage Forms. Journal of Pharmaceutics No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-498474
American Medical Association (AMA)
Deepakumari, Hemavathi Nagaraju& Revanasiddappa, Hosakere Doddarevanna. Use of the Charge Transfer Reactions for the Spectrophotometric Determination of Risperidone in Pure and in Dosage Forms. Journal of Pharmaceutics. 2012. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-498474
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-498474