Molecular and Genetic Basis of Inherited Nephrotic Syndrome
Joint Authors
Gesualdo, Loreto
Iolascon, Achille
Piemontese, Matteo
Gigante, Maddalena
Aucella, Filippo
Source
International Journal of Nephrology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-06
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Nephrotic syndrome is an heterogeneous disease characterized by increased permeability of the glomerular filtration barrier for macromolecules.
Podocytes, the visceral epithelial cells of glomerulus, play critical role in ultrafiltration of plasma and are involved in a wide number of inherited and acquired glomerular diseases.
The identification of mutations in nephrin and other podocyte genes as causes of genetic forms of nephrotic syndrome has revealed new important aspects of the pathogenesis of proteinuric kidney diseases and expanded our knowledge of the glomerular biology.
Moreover, a novel concept of a highly dynamic slit diaphragm proteins is emerging.
The most significant discoveries in our understanding of the structure and function of the glomerular filtration barrier are reviewed in this paper.
American Psychological Association (APA)
Gigante, Maddalena& Piemontese, Matteo& Gesualdo, Loreto& Iolascon, Achille& Aucella, Filippo. 2011. Molecular and Genetic Basis of Inherited Nephrotic Syndrome. International Journal of Nephrology،Vol. 2011, no. 2011, pp.1-15.
https://search.emarefa.net/detail/BIM-498475
Modern Language Association (MLA)
Gigante, Maddalena…[et al.]. Molecular and Genetic Basis of Inherited Nephrotic Syndrome. International Journal of Nephrology No. 2011 (2011), pp.1-15.
https://search.emarefa.net/detail/BIM-498475
American Medical Association (AMA)
Gigante, Maddalena& Piemontese, Matteo& Gesualdo, Loreto& Iolascon, Achille& Aucella, Filippo. Molecular and Genetic Basis of Inherited Nephrotic Syndrome. International Journal of Nephrology. 2011. Vol. 2011, no. 2011, pp.1-15.
https://search.emarefa.net/detail/BIM-498475
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-498475