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An Estrogen Model : The Relationship between Body Mass Index, Menopausal Status, Estrogen Replacement Therapy, and Breast Cancer Risk
Joint Authors
Dinh, Tuan A.
Smith, Robert A.
Green, Linda E.
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-16
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
We present a mathematical model that lends support to the hypothesis that estrogen levels mediate the complex relationship between body mass index (BMI), menopausal status, estrogen-only hormone replacement therapy (HRT), and breast cancer risk.
The model predicts a decrease in the relative risk of breast cancer of 3% per unit increase in BMI (kg/m2) for premenopausal women and an increase in the relative risk of 4% per unit increase in BMI for postmenopausal women who are not HRT users.
When comparing postmenopausal women who use estrogen-only HRT to postmenopausal women who do not use HRT, the model predicts an increased risk of breast cancer associated with use of estrogen that diminishes with increasing BMI, with a relative risk of 1.6 for women with BMI of 18, 1.2 for women with BMI of 25, and 1.0 for women with BMI≥30.
Model predictions agree with data from five major epidemiological studies.
American Psychological Association (APA)
Green, Linda E.& Dinh, Tuan A.& Smith, Robert A.. 2012. An Estrogen Model : The Relationship between Body Mass Index, Menopausal Status, Estrogen Replacement Therapy, and Breast Cancer Risk. Computational and Mathematical Methods in Medicine،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-498484
Modern Language Association (MLA)
Green, Linda E.…[et al.]. An Estrogen Model : The Relationship between Body Mass Index, Menopausal Status, Estrogen Replacement Therapy, and Breast Cancer Risk. Computational and Mathematical Methods in Medicine No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-498484
American Medical Association (AMA)
Green, Linda E.& Dinh, Tuan A.& Smith, Robert A.. An Estrogen Model : The Relationship between Body Mass Index, Menopausal Status, Estrogen Replacement Therapy, and Breast Cancer Risk. Computational and Mathematical Methods in Medicine. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-498484
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-498484