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Postulated Role of Vasoactive Neuropeptide-Related Immunopathology of the Blood Brain Barrier and Virchow-Robin Spaces in the Aetiology of Neurological-Related Conditions
Joint Authors
Staines, D. R.
Brenu, E. W.
Marshall-Gradisnik, S.
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-02-16
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Vasoactive neuropeptides (VNs) such as pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) have critical roles as neurotransmitters, vasodilators including perfusion and hypoxia regulators, as well as immune and nociception modulators.
They have key roles in blood vessels in the central nervous system (CNS) including maintaining functional integrity of the blood brain barrier (BBB) and blood spinal barrier (BSB).
VNs are potent activators of adenylate cyclase and thus also have a key role in cyclic AMP production affecting regulatory T cell and other immune functions.
Virchow-Robin spaces (VRSs) are perivascular compartments surrounding small vessels within the CNS and contain VNs.
Autoimmunity of VNs or VN receptors may affect BBB and VRS function and, therefore, may contribute to the aetiology of neurological-related conditions including multiple sclerosis, Parkinson's disease, and amyotrophic lateral sclerosis.
VN autoimmunity will likely affect CNS and immunological homeostasis.
Various pharmacological and immunological treatments including phosphodiesterase inhibitors and plasmapheresis may be indicated.
American Psychological Association (APA)
Staines, D. R.& Brenu, E. W.& Marshall-Gradisnik, S.. 2009. Postulated Role of Vasoactive Neuropeptide-Related Immunopathology of the Blood Brain Barrier and Virchow-Robin Spaces in the Aetiology of Neurological-Related Conditions. Mediators of Inflammation،Vol. 2008, no. 2008, pp.1-5.
https://search.emarefa.net/detail/BIM-498489
Modern Language Association (MLA)
Staines, D. R.…[et al.]. Postulated Role of Vasoactive Neuropeptide-Related Immunopathology of the Blood Brain Barrier and Virchow-Robin Spaces in the Aetiology of Neurological-Related Conditions. Mediators of Inflammation No. 2008 (2008), pp.1-5.
https://search.emarefa.net/detail/BIM-498489
American Medical Association (AMA)
Staines, D. R.& Brenu, E. W.& Marshall-Gradisnik, S.. Postulated Role of Vasoactive Neuropeptide-Related Immunopathology of the Blood Brain Barrier and Virchow-Robin Spaces in the Aetiology of Neurological-Related Conditions. Mediators of Inflammation. 2009. Vol. 2008, no. 2008, pp.1-5.
https://search.emarefa.net/detail/BIM-498489
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-498489