The Relationship between Coenzyme Q10, Oxidative Stress, and Antioxidant Enzymes Activities and Coronary Artery Disease
Joint Authors
Lin, Ping-Ting
Hsia, Simon
Huang, Yi-Chia
Lin, Yi-Chin
Ko, Ya-Wen
Lee, Bor-Jen
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-03
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
A higher oxidative stress may contribute to the pathogenesis of coronary artery disease (CAD).
The purpose of this study was to investigate the relationship between coenzyme Q10 concentration and lipid peroxidation, antioxidant enzymes activities and the risk of CAD.
Patients who were identified by cardiac catheterization as having at least 50% stenosis of one major coronary artery were assigned to the case group (n=51).
The control group (n=102) comprised healthy individuals with normal blood biochemical values.
The plasma coenzyme Q10, malondialdehyde (MDA) and antioxidant enzymes activities (catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx)) were measured.
Subjects with CAD had significant lower plasma coenzyme Q10, CAT and GPx activities and higher MDA and SOD levels compared to those of the control group.
The plasma coenzyme Q10 was positively correlated with CAT and GPx activities and negatively correlated with MDA and SOD.
However, the correlations were not significant after adjusting for the potential confounders of CAD with the exception of SOD.
A higher level of plasma coenzyme Q10 (≥0.52 μmol/L) was significantly associated with reducing the risk of CAD.
Our results support the potential cardioprotective impact of coenzyme Q10.
American Psychological Association (APA)
Lee, Bor-Jen& Lin, Yi-Chin& Huang, Yi-Chia& Ko, Ya-Wen& Hsia, Simon& Lin, Ping-Ting. 2012. The Relationship between Coenzyme Q10, Oxidative Stress, and Antioxidant Enzymes Activities and Coronary Artery Disease. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-498513
Modern Language Association (MLA)
Lee, Bor-Jen…[et al.]. The Relationship between Coenzyme Q10, Oxidative Stress, and Antioxidant Enzymes Activities and Coronary Artery Disease. The Scientific World Journal No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-498513
American Medical Association (AMA)
Lee, Bor-Jen& Lin, Yi-Chin& Huang, Yi-Chia& Ko, Ya-Wen& Hsia, Simon& Lin, Ping-Ting. The Relationship between Coenzyme Q10, Oxidative Stress, and Antioxidant Enzymes Activities and Coronary Artery Disease. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-498513
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-498513