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1,4-dihydroxy-2-naphthoic Acid Induces Apoptosis in Human Keratinocyte : Potential Application for Psoriasis Treatment
Joint Authors
Mok, Chong-Fai
Cheng, Christopher Hon-Ki
Xie, Chuan-Ming
Lin, Zhi-Xiu
Sham, Kathy Wai-Yan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-11
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
Psoriasis, which affects approximately 1–3% of the population worldwide, is a chronic inflammatory skin disorder characterized by epidermal keratinocytes hyperproliferation, abnormal differentiation, and inflammatory infiltration.
Decrease in keratinocyte apoptosis is a specific pathogenic phenomenon in psoriasis.
Chinese herbs have been used for the treatment of psoriasis in China showing promising effect in clinical trials.
A traditional Chinese medicine has relatively fewer side effects with longer remission time and lower recurrence rate.
The extract of Rubia cordifolia L.
(EA) was previously found by us to induce HaCaT keratinocytes apoptosis.
In this study we identified one of the components in Rubia cordifolia L., the anthraquinone precursor 1,4-dihydroxy-2-naphthoic acid (DHNA), induces HaCaT keratinocytes apoptosis through G0/G1 cell cycle arrest.
We have also demonstrated that DHNA acts through both caspase-dependent and caspase-independent pathways.
Besides, cytotoxicity and IL-1α release assays indicate that DHNA causes less irritation problems than dithranol, which is commonly employed to treat psoriasis in many countries.
Since DHNA possesses similar apoptotic effects on keratinocytes as dithranol but causes less irritation, DHNA therefore constitutes a promising alternative agent for treating psoriasis.
Our studies also provide an insight on the potential of using EA and DHNA, alternatively, as a safe and effective treatment modality for psoriasis.
American Psychological Association (APA)
Mok, Chong-Fai& Xie, Chuan-Ming& Sham, Kathy Wai-Yan& Lin, Zhi-Xiu& Cheng, Christopher Hon-Ki. 2013. 1,4-dihydroxy-2-naphthoic Acid Induces Apoptosis in Human Keratinocyte : Potential Application for Psoriasis Treatment. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-19.
https://search.emarefa.net/detail/BIM-498523
Modern Language Association (MLA)
Mok, Chong-Fai…[et al.]. 1,4-dihydroxy-2-naphthoic Acid Induces Apoptosis in Human Keratinocyte : Potential Application for Psoriasis Treatment. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-19.
https://search.emarefa.net/detail/BIM-498523
American Medical Association (AMA)
Mok, Chong-Fai& Xie, Chuan-Ming& Sham, Kathy Wai-Yan& Lin, Zhi-Xiu& Cheng, Christopher Hon-Ki. 1,4-dihydroxy-2-naphthoic Acid Induces Apoptosis in Human Keratinocyte : Potential Application for Psoriasis Treatment. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-19.
https://search.emarefa.net/detail/BIM-498523
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-498523