Functional Inflammatory Genotypes in Ischemic Stroke : Could We Use Them to Predict Age of Onset and Long-Term Outcome?

Abstract EN

Functional single-nucleotide polymorphisms (SNPs) of inflammatory cytokines have been previously related to the occurrence of an ischemic stroke (IS).

We investigated whether five functional SNPs (i.e., TNF-α-308G>A, IL6-174G>C, IL12B 1188A>C, IL4-589C>T, and IL10-1082G>A) might be associated with the age of onset and 6-month outcome of an acute IS.

A probe-free real-time PCR methodology was used to genotype 145 consecutively admitted cases with a first-ever IS.

Simple Kaplan-Mayer and adjusted Cox regression analyses showed no association between inflammatory genotypes and the age of IS onset.

IL6-174G>C, IL12B 1188A>C, IL4-589C>T, and IL10-1082G>A were not found to significantly contribute to the long-term outcome of the disease.

However, carriage of the TNF-α-308 GG genotype was significantly associated with reduced odds for an adverse outcome.

Larger studies are needed to confirm our results.