Estimate of FDG Excretion by means of Compartmental Analysis and Ant Colony Optimization of Nuclear Medicine Data
Joint Authors
Garbarino, Sara
Piana, Michele
Massollo, Michela
Brignone, Massimo
Sambuceti, Gianmario
Caviglia, Giacomo
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
[18F]fluoro-2-deoxy-D-glucose (FDG) is one of the most utilized tracers for positron emission tomography (PET) applications in oncology.
FDG-PET relies on higher glycolytic activity in tumors compared to normal structures as the basis of image contrast.
As a glucose analog, FDG is transported into malignant cells which typically exhibit an increased radioactivity.
However, different from glucose, FDG is not reabsorbed by the renal system and is excreted to the bladder.
The present paper describes a novel computational method for the quantitative assessment of this excretion process.
The method is based on a compartmental analysis of FDG-PET data in which the excretion process is explicitly accounted for by the bladder compartment and on the application of an ant colony optimization (ACO) algorithm for the determination of the tracer coefficients describing the FDG transport effectiveness.
The validation of this approach is performed by means of both synthetic data and real measurements acquired by a PET device for small animals (micro-PET).
Possible oncological applications of the results are discussed in the final section.
American Psychological Association (APA)
Garbarino, Sara& Caviglia, Giacomo& Brignone, Massimo& Massollo, Michela& Sambuceti, Gianmario& Piana, Michele. 2013. Estimate of FDG Excretion by means of Compartmental Analysis and Ant Colony Optimization of Nuclear Medicine Data. Computational and Mathematical Methods in Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-498551
Modern Language Association (MLA)
Garbarino, Sara…[et al.]. Estimate of FDG Excretion by means of Compartmental Analysis and Ant Colony Optimization of Nuclear Medicine Data. Computational and Mathematical Methods in Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-498551
American Medical Association (AMA)
Garbarino, Sara& Caviglia, Giacomo& Brignone, Massimo& Massollo, Michela& Sambuceti, Gianmario& Piana, Michele. Estimate of FDG Excretion by means of Compartmental Analysis and Ant Colony Optimization of Nuclear Medicine Data. Computational and Mathematical Methods in Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-498551
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-498551