Dynamic Changes of Neuroskeletal Proteins in DRGs Underlie Impaired Axonal Maturation and Progressive Axonal Degeneration in Type 1 Diabetes
Joint Authors
Kamiya, Hideki
Zhang, Weixian
Sima, Anders A. F.
Source
Experimental Diabetes Research
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-10-12
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
We investigated mechanisms underlying progressive axonal dysfunction and structural deficits in type 1 BB/Wor-rats from 1 week to 10 month diabetes duration.
Motor and sensory conduction velocities were decreased after 4 and 6 weeks of diabetes and declined further over the remaining 9 months.
Myelinated sural nerve fibers showed progressive deficits in fiber numbers and sizes.
Structural deficits in unmyelinated axonal size were evident at 2 month and deficits in number were present at 4 mo.
These changes were preceded by decreased availability of insulin, C-peptide and IGF-1 and decreased expression of neurofilaments and β-III-tubulin.
Upregulation of phosphorylating stress kinases like Cdk5, p-GSK-3β, and p42/44 resulted in increased phosphorylation of neurofilaments.
Increasing activity of p-GSK-3β correlated with increasing phosphorylation of NFH, whereas decreasing Cdk5 correlated with diminishing phosphorylation of NFM.
The data suggest that impaired neurotrophic support results in sequentially impaired synthesis and postranslational modifications of neuroskeletal proteins, resulting in progressive deficits in axonal function, maturation and size.
American Psychological Association (APA)
Kamiya, Hideki& Zhang, Weixian& Sima, Anders A. F.. 2009. Dynamic Changes of Neuroskeletal Proteins in DRGs Underlie Impaired Axonal Maturation and Progressive Axonal Degeneration in Type 1 Diabetes. Experimental Diabetes Research،Vol. 2009, no. 2009, pp.1-14.
https://search.emarefa.net/detail/BIM-498566
Modern Language Association (MLA)
Kamiya, Hideki…[et al.]. Dynamic Changes of Neuroskeletal Proteins in DRGs Underlie Impaired Axonal Maturation and Progressive Axonal Degeneration in Type 1 Diabetes. Experimental Diabetes Research No. 2009 (2009), pp.1-14.
https://search.emarefa.net/detail/BIM-498566
American Medical Association (AMA)
Kamiya, Hideki& Zhang, Weixian& Sima, Anders A. F.. Dynamic Changes of Neuroskeletal Proteins in DRGs Underlie Impaired Axonal Maturation and Progressive Axonal Degeneration in Type 1 Diabetes. Experimental Diabetes Research. 2009. Vol. 2009, no. 2009, pp.1-14.
https://search.emarefa.net/detail/BIM-498566
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-498566