The Use of Fractal Dimension Analysis in Estimation of Blood Vessels Shape in Transplantable Mammary Adenocarcinoma in Wistar Rats after Photodynamic Therapy Combined with Cysteine Protease Inhibitors
Joint Authors
Ziółkowski, Piotr
Osiecka, Beata J.
Jurczyszyn, Kamil
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-06
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Fractal dimension analysis (FDA) is modern mathematical method widely used to describing of complex and chaotic shapes when classic methods fail.
The main aim of this study was evaluating the influence of photodynamic therapy (PDT) with cystein proteases inhibitors (CPI) on the number and morphology of blood vessels inside tumor and on increase of effectiveness of combined therapy in contrast to PDT and CPI used separately.
Animals were divided into four groups: control, treated using only PDT, treated using only CPI and treated using combined therapy, PDT and CPI.
Results showed that time of animal survival and depth of necrosis inside tumor were significantly higher in CPI+PDT group in contrast to other groups.
The higher value of fractal dimension (FD) was observed in control group, while the lowest value was found in the group which was treated by cystein protease inhibitors.
The differences between FD were observed in CPI group and PDT+CPI group in comparison to control group.
Our results revealed that fractal dimension analysis is a very useful tool in estimating differences between irregular shapes like blood vessels in PDT treated tumors.
Thus, the implementation of FDA algorithms could be useful method in evaluating the efficacy of PDT.
American Psychological Association (APA)
Jurczyszyn, Kamil& Osiecka, Beata J.& Ziółkowski, Piotr. 2012. The Use of Fractal Dimension Analysis in Estimation of Blood Vessels Shape in Transplantable Mammary Adenocarcinoma in Wistar Rats after Photodynamic Therapy Combined with Cysteine Protease Inhibitors. Computational and Mathematical Methods in Medicine،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-498567
Modern Language Association (MLA)
Jurczyszyn, Kamil…[et al.]. The Use of Fractal Dimension Analysis in Estimation of Blood Vessels Shape in Transplantable Mammary Adenocarcinoma in Wistar Rats after Photodynamic Therapy Combined with Cysteine Protease Inhibitors. Computational and Mathematical Methods in Medicine No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-498567
American Medical Association (AMA)
Jurczyszyn, Kamil& Osiecka, Beata J.& Ziółkowski, Piotr. The Use of Fractal Dimension Analysis in Estimation of Blood Vessels Shape in Transplantable Mammary Adenocarcinoma in Wistar Rats after Photodynamic Therapy Combined with Cysteine Protease Inhibitors. Computational and Mathematical Methods in Medicine. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-498567
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-498567