Cholangiopathy with Respect to Biliary Innate Immunity
Joint Authors
Harada, Kenichi
Nakanuma, Yasuni
Source
International Journal of Hepatology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-11
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Biliary innate immunity is involved in the pathogenesis of cholangiopathies in cases of biliary disease.
Cholangiocytes possess Toll-like receptors (TLRs) which recognize pathogen-associated molecular patterns (PAMPs) and play a pivotal role in the innate immune response.
Tolerance to bacterial PAMPs such as lipopolysaccharides is also important to maintain homeostasis in the biliary tree, but tolerance to double-stranded RNA (dsRNA) is not found.
Moreover, in primary biliary cirrhosis (PBC) and biliary atresia, biliary innate immunity is closely associated with the dysregulation of the periductal cytokine milieu and the induction of biliary apoptosis and epithelial-mesenchymal transition (EMT), forming in disease-specific cholangiopathy.
Biliary innate immunity is associated with the pathogenesis of various cholangiopathies in biliary diseases as well as biliary defense systems.
American Psychological Association (APA)
Harada, Kenichi& Nakanuma, Yasuni. 2011. Cholangiopathy with Respect to Biliary Innate Immunity. International Journal of Hepatology،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-498590
Modern Language Association (MLA)
Harada, Kenichi& Nakanuma, Yasuni. Cholangiopathy with Respect to Biliary Innate Immunity. International Journal of Hepatology No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-498590
American Medical Association (AMA)
Harada, Kenichi& Nakanuma, Yasuni. Cholangiopathy with Respect to Biliary Innate Immunity. International Journal of Hepatology. 2011. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-498590
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-498590