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The Role of Haptoglobin Genotypes in Chagas Disease
Joint Authors
Mundaray Fernández, Ninomar
Fernández-Mestre, Mercedes
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-23
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Although the number of people infected with T.
cruzi is on the rise, host genetic and immune components that are crucial in the development of the Chagas disease have been discovered.
We investigated the frequency of polymorphisms in the gene encoding haptoglobin of patients with chronic Chagas disease.
The results suggest that while the HP1-1 genotype may confer protection against infection and the development of chronic Chagas disease due to the rapid metabolism of the Hp1-1-Hb complex and its anti-inflammatory activity, the presence of HP2-2 genotype may increase susceptibility towards a chronic condition of the disease due to a slow metabolism of the Hp2-2-Hb complex, lower antioxidant activity, and increased inflammatory reactivity, which lead to cell damage and a deterioration of the cardiac function.
Finally, correlations between HP genotypes in different age groups and cardiac manifestations suggest that HP polymorphism could influence the prognosis of this infectious disease.
This study shows some of the relevant aspects of the haptoglobin gene polymorphism and its implications in the T.
cruzi infection.
American Psychological Association (APA)
Mundaray Fernández, Ninomar& Fernández-Mestre, Mercedes. 2014. The Role of Haptoglobin Genotypes in Chagas Disease. Disease Markers،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-498597
Modern Language Association (MLA)
Mundaray Fernández, Ninomar& Fernández-Mestre, Mercedes. The Role of Haptoglobin Genotypes in Chagas Disease. Disease Markers No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-498597
American Medical Association (AMA)
Mundaray Fernández, Ninomar& Fernández-Mestre, Mercedes. The Role of Haptoglobin Genotypes in Chagas Disease. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-498597
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-498597