Mechanisms Underlying the Osteo- and Adipo-Differentiation of Human Mesenchymal Stem Cells
Joint Authors
Zhang, Yu
Tobiasch, Edda
Delling, Julia
Khan, Dilaware
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-12
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
Human mesenchymal stem cells (hMSCs) are considered a promising cell source for regenerative medicine, because they have the potential to differentiate into a variety of lineages among which the mesoderm-derived lineages such adipo- or osteogenesis are investigated best.
Human MSCs can be harvested in reasonable to large amounts from several parts of the patient’s body and due to this possible autologous origin, allorecognition can be avoided.
In addition, even in allogenic origin-derived donor cells, hMSCs generate a local immunosuppressive microenvironment, causing only a weak immune reaction.
There is an increasing need for bone replacement in patients from all ages, due to a variety of reasons such as a new recreational behavior in young adults or age-related diseases.
Adipogenic differentiation is another interesting lineage, because fat tissue is considered to be a major factor triggering atherosclerosis that ultimately leads to cardiovascular diseases, the main cause of death in industrialized countries.
However, understanding the differentiation process in detail is obligatory to achieve a tight control of the process for future clinical applications to avoid undesired side effects.
In this review, the current findings for adipo- and osteo-differentiation are summarized together with a brief statement on first clinical trials.
American Psychological Association (APA)
Zhang, Yu& Khan, Dilaware& Delling, Julia& Tobiasch, Edda. 2012. Mechanisms Underlying the Osteo- and Adipo-Differentiation of Human Mesenchymal Stem Cells. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-498614
Modern Language Association (MLA)
Zhang, Yu…[et al.]. Mechanisms Underlying the Osteo- and Adipo-Differentiation of Human Mesenchymal Stem Cells. The Scientific World Journal No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-498614
American Medical Association (AMA)
Zhang, Yu& Khan, Dilaware& Delling, Julia& Tobiasch, Edda. Mechanisms Underlying the Osteo- and Adipo-Differentiation of Human Mesenchymal Stem Cells. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-498614
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-498614