Regulation of ROS Production and Vascular Function by Carbon Monoxide
Joint Authors
Por, Elaine D.
Kwon, Young-Guen
Choi, Yoon Kyung
Kim, Young-Myeong
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-09
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Carbon monoxide (CO) is a gaseous molecule produced from heme by heme oxygenase (HO).
CO interacts with reduced iron of heme-containing proteins, leading to its involvement in various cellular events via its production of mitochondrial reactive oxygen species (ROS).
CO-mediated ROS production initiates intracellular signal events, which regulate the expression of adaptive genes implicated in oxidative stress and functions as signaling molecule for promoting vascular functions, including angiogenesis and mitochondrial biogenesis.
Therefore, CO generated either by exogenous delivery or by HO activity can be fundamentally involved in regulating mitochondria-mediated redox cascades for adaptive gene expression and improving blood circulation (i.e., O2 delivery) via neovascularization, leading to the regulation of mitochondrial energy metabolism.
This paper will highlight the biological effects of CO on ROS generation and cellular redox changes involved in mitochondrial metabolism and angiogenesis.
Moreover, cellular mechanisms by which CO is exploited for disease prevention and therapeutic applications will also be discussed.
American Psychological Association (APA)
Choi, Yoon Kyung& Por, Elaine D.& Kwon, Young-Guen& Kim, Young-Myeong. 2012. Regulation of ROS Production and Vascular Function by Carbon Monoxide. Oxidative Medicine and Cellular Longevity،Vol. 2012, no. 2012, pp.1-17.
https://search.emarefa.net/detail/BIM-498660
Modern Language Association (MLA)
Choi, Yoon Kyung…[et al.]. Regulation of ROS Production and Vascular Function by Carbon Monoxide. Oxidative Medicine and Cellular Longevity No. 2012 (2012), pp.1-17.
https://search.emarefa.net/detail/BIM-498660
American Medical Association (AMA)
Choi, Yoon Kyung& Por, Elaine D.& Kwon, Young-Guen& Kim, Young-Myeong. Regulation of ROS Production and Vascular Function by Carbon Monoxide. Oxidative Medicine and Cellular Longevity. 2012. Vol. 2012, no. 2012, pp.1-17.
https://search.emarefa.net/detail/BIM-498660
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-498660