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The CYTO-PV : A Large-Scale Trial Testing the Intensity of CYTOreductive Therapy to Prevent Cardiovascular Events in Patients with Polycythemia Vera
Joint Authors
Barbui, Tiziano
Marchioli, Roberto
Specchia, Giorgina
Mennitto, Maria Rosaria
Finazzi, Guido
Masciulli, Arianna
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-17
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Polycythemia vera (PV) is a chronic myeloproliferative disorder whose major morbidity and mortality are thrombohaemorragic events.
Current guidelines advise maintaining hematocrit (HCT) level below 45% in males and 42% in females.
Such targets lean on pathophysiological reasoning, while evidence from ECLAP and PVSG-01, the two largest prospective studies in this disease, suggests no difference in the rate of thrombosis in patients maintained at different HCT values below 50%–52%.
Cytoreductive therapy in PV (CYTO-PV) is a multicenter, randomized, and controlled trial assess the benefit/risk profile of cytoreductive therapy with phlebotomy or HU aimed at maintaining HCT < 45% versus maintaining HCT in the range 45%–50%.
CYTO-PV is being conducted in the framework of the Gruppo Italiano Malattie Ematologiche nell'Adulto (GIMEMA) and is funded by the Italian Drug Agency (AIFA).
It is an independent trial with broad recruitment criteria to mimic clinical practice.
We describe here the study and its advancement status.
Conclusions.
Clinical research in rare disease can be carried out with limited funds, provided a research hypothesis is felt as clinically relevant by a scientific community willing to share knowledge on the outcome of clinical practice, thus producing scientific results useful to improve treatment and prognosis of patients.
American Psychological Association (APA)
Marchioli, Roberto& Finazzi, Guido& Specchia, Giorgina& Masciulli, Arianna& Mennitto, Maria Rosaria& Barbui, Tiziano. 2011. The CYTO-PV : A Large-Scale Trial Testing the Intensity of CYTOreductive Therapy to Prevent Cardiovascular Events in Patients with Polycythemia Vera. Thrombosis،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-498662
Modern Language Association (MLA)
Marchioli, Roberto…[et al.]. The CYTO-PV : A Large-Scale Trial Testing the Intensity of CYTOreductive Therapy to Prevent Cardiovascular Events in Patients with Polycythemia Vera. Thrombosis No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-498662
American Medical Association (AMA)
Marchioli, Roberto& Finazzi, Guido& Specchia, Giorgina& Masciulli, Arianna& Mennitto, Maria Rosaria& Barbui, Tiziano. The CYTO-PV : A Large-Scale Trial Testing the Intensity of CYTOreductive Therapy to Prevent Cardiovascular Events in Patients with Polycythemia Vera. Thrombosis. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-498662
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-498662