Genetic Mechanisms in Aspirin-Exacerbated Respiratory Disease
Joint Authors
Shrestha Palikhe, Nami
Kim, Seung-Hyun
Jin, Hyun Jung
Park, Hae-Sim
Nam, Young Hee
Hwang, Eui-Kyung
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-07
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Aspirin-exacerbated respiratory disease (AERD) refers to the development of bronchoconstriction in asthmatics following the exposure to aspirin or other nonsteroidal anti-inflammatory drugs.
The key pathogenic mechanisms associated with AERD are the overproduction of cysteinyl leukotrienes (CysLTs) and increased CysLTR1 expression in the airway mucosa and decreased lipoxin and PGE2 synthesis.
Genetic studies have suggested a role for variability of genes in disease susceptibility and the response to medication.
Potential genetic biomarkers contributing to the AERD phenotype include HLA-DPB1, LTC4S, ALOX5, CYSLT, PGE2, TBXA2R, TBX21, MS4A2, IL10, ACE, IL13, KIF3A, SLC22A2, CEP68, PTGER, and CRTH2 and a four-locus SNP set composed of B2ADR, CCR3, CysLTR1, and FCER1B.
Future areas of investigation need to focus on comprehensive approaches to identifying biomarkers for early diagnosis.
American Psychological Association (APA)
Shrestha Palikhe, Nami& Kim, Seung-Hyun& Jin, Hyun Jung& Hwang, Eui-Kyung& Nam, Young Hee& Park, Hae-Sim. 2011. Genetic Mechanisms in Aspirin-Exacerbated Respiratory Disease. Journal of Allergy،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-498715
Modern Language Association (MLA)
Shrestha Palikhe, Nami…[et al.]. Genetic Mechanisms in Aspirin-Exacerbated Respiratory Disease. Journal of Allergy No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-498715
American Medical Association (AMA)
Shrestha Palikhe, Nami& Kim, Seung-Hyun& Jin, Hyun Jung& Hwang, Eui-Kyung& Nam, Young Hee& Park, Hae-Sim. Genetic Mechanisms in Aspirin-Exacerbated Respiratory Disease. Journal of Allergy. 2011. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-498715
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-498715