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MicroRNAs in Vascular Biology
Author
Source
International Journal of Vascular Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-26
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Vascular inflammation is an important component of the pathophysiology of cardiovascular diseases, such as hypertension, atherosclerosis, and aneurysms.
All vascular cells, including endothelial cells (ECs) and vascular smooth muscle cells (VSMCs), and infiltrating cells, such as macrophages, orchestrate a series of pathological events.
Despite dramatic improvements in the treatment of atherosclerosis, the molecular basis of vascular inflammation is not well understood.
In the last decade, microRNAs (miRNAs) have been revealed as novel regulators of vascular inflammation.
Each miRNAs suppresses a set of genes, forming complex regulatory network.
This paper provides an overview of current advances that have been made in revealing the roles of miRNAs during vascular inflammation.
Recent studies show that miRNAs not only exist inside cells but also circulate in blood.
These circulating miRNAs are useful biomarkers for diagnosis of cardiovascular diseases.
Furthermore, recent studies demonstrate that circulating miRNAs are delivered into certain recipient cells and act as messengers.
These studies suggest that miRNAs provide new therapeutic opportunities.
American Psychological Association (APA)
Yamakuchi, Munekazu. 2012. MicroRNAs in Vascular Biology. International Journal of Vascular Medicine،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-498717
Modern Language Association (MLA)
Yamakuchi, Munekazu. MicroRNAs in Vascular Biology. International Journal of Vascular Medicine No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-498717
American Medical Association (AMA)
Yamakuchi, Munekazu. MicroRNAs in Vascular Biology. International Journal of Vascular Medicine. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-498717
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-498717