Cholangiocarcinomas : New Insights from the Discovery of Stem Cell Niches in Peribiliary Glands of the Biliary Tree
Joint Authors
Torrice, Alessia
Reid, Lola McAdams
Alvaro, Domenico
Cardinale, Vincenzo
Gaudio, Eugenio
Wang, Yunfang
Consiglia Bragazzi, Maria
Carpino, Guido
Source
Case Reports in Ophthalmological Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Peribiliary glands (PBGs) are located in the large intrahepatic and extrahepatic bile ducts.
Although they were described many years ago, their functions have been elucidated only in the last couple of years when our group demonstrated that PBGs are niches of multipotent stem/progenitor cells of endodermal origin.
These cells express genes of multipotency and can be rapidly differentiated in vitro into hepatocytes, cholangiocytes, and endocrine pancreatic cells.
PBGs share common features, in terms of stem/progenitor cell niches, with pancreatic duct glands and colon crypts, glandular structures representing in the adult life the endodermal remnants of fetal life.
PBG stem/progenitor cells participate in the renewal of surface biliary epithelium and are active players in chronic pathologies of the biliary tree as well as in cholangiocarcinomas (CCA).
Specifically, a large amount of recent evidence indicates that the pure mucin-CCA originates from PBGs; this could explain the similarities with pancreatic ductal adenocarcinoma and colorectal cancer, which also originate from transformed gland cells.
In this paper, we summarized our recent findings concerning structure and functions of PBGs with the implications for liver pathophysiology and, specifically, for cancers of the biliary tree.
American Psychological Association (APA)
Cardinale, Vincenzo& Consiglia Bragazzi, Maria& Carpino, Guido& Torrice, Alessia& Wang, Yunfang& Reid, Lola McAdams…[et al.]. 2014. Cholangiocarcinomas : New Insights from the Discovery of Stem Cell Niches in Peribiliary Glands of the Biliary Tree. Case Reports in Ophthalmological Medicine،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-498724
Modern Language Association (MLA)
Cardinale, Vincenzo…[et al.]. Cholangiocarcinomas : New Insights from the Discovery of Stem Cell Niches in Peribiliary Glands of the Biliary Tree. Case Reports in Ophthalmological Medicine No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-498724
American Medical Association (AMA)
Cardinale, Vincenzo& Consiglia Bragazzi, Maria& Carpino, Guido& Torrice, Alessia& Wang, Yunfang& Reid, Lola McAdams…[et al.]. Cholangiocarcinomas : New Insights from the Discovery of Stem Cell Niches in Peribiliary Glands of the Biliary Tree. Case Reports in Ophthalmological Medicine. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-498724
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-498724