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Immune Modulation by Schistosoma mansoni Antigens in NOD Mice : Effects on Both Innate and Adaptive Immune Systems
Joint Authors
Dunne, David W.
Cooke, Anne
Burton, Oliver T.
Gibbs, Sarah
Miller, Nigel
Jones, Frances M.
Zaccone, Paola
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-03-01
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
We have shown that Schistosoma mansoni egg soluble antigen (SEA) prevents diabetes in the nonobese diabetic (NOD) mouse inducing functional changes in antigen presenting cells (APCs) and expanding T helper (Th) 2 and regulatory T cell (Treg) responses.
A Th2 response to S.
mansoni infection or its antigens is key to both the establishment of tolerance and successfully reproduction in the host.
More recently we demonstrated that SEA treatment upregulates bioactive TGFβ on T cells with consequent expansion of Foxp3+ Tregs, and these cells might be important in SEA-mediated diabetes prevention together with Th2 cells.
In this study we profile further the phenotypic changes that SEA induces on APCs, with particular attention to cytokine expression and markers of macrophage alternative activation.
Our studies suggest that TGFβ from T cells is important not just for Treg expansion but also for the successful Th2 response to SEA, and therefore, for diabetes prevention in the NOD mouse.
American Psychological Association (APA)
Zaccone, Paola& Burton, Oliver T.& Gibbs, Sarah& Miller, Nigel& Jones, Frances M.& Dunne, David W.…[et al.]. 2010. Immune Modulation by Schistosoma mansoni Antigens in NOD Mice : Effects on Both Innate and Adaptive Immune Systems. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-498746
Modern Language Association (MLA)
Zaccone, Paola…[et al.]. Immune Modulation by Schistosoma mansoni Antigens in NOD Mice : Effects on Both Innate and Adaptive Immune Systems. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-11.
https://search.emarefa.net/detail/BIM-498746
American Medical Association (AMA)
Zaccone, Paola& Burton, Oliver T.& Gibbs, Sarah& Miller, Nigel& Jones, Frances M.& Dunne, David W.…[et al.]. Immune Modulation by Schistosoma mansoni Antigens in NOD Mice : Effects on Both Innate and Adaptive Immune Systems. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-498746
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-498746