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Expression Patterns of Cancer-Testis Antigens in Human Embryonic Stem Cells and Their Cell Derivatives Indicate Lineage Tracks
Joint Authors
Gordeeva, Olga
Poljanskaya, Galina
Koltsova, Anna
Krylova, Tatyana
Yakovleva, Tatyana
Lifantseva, Nadya
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-18
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
Pluripotent stem cells can differentiate into various lineages but undergo genetic and epigenetic changes during long-term cultivation and, therefore, require regular monitoring.
The expression patterns of cancer-testis antigens (CTAs) MAGE-A2, -A3, -A4, -A6, -A8, -B2, and GAGE were examined in undifferentiated human embryonic stem (hES) cells, their differentiated derivatives, teratocarcinoma (hEC) cells, and cancer cell lines of neuroectodermal and mesodermal origin.
Undifferentiated hES cells and embryoid body cells expressed MAGE-A3, -A6, -A4, -A8, and GAGEs while later differentiated derivatives expressed only MAGE-A8 or MAGE-A4.
Likewise, mouse pluripotent stem cells also express CTAs of Magea but not Mageb family.
Despite similarity of the hES and hEC cell expression patterns, MAGE-A2 and MAGE-B2 were detected only in hEC cells but not in hES cells.
Moreover, our analysis has shown that CTAs are aberrantly expressed in cancer cell lines and display low tissue specificity.
The identification of CTA expression patterns in pluripotent stem cells and their derivatives may be useful for isolation of abnormally CTA-expressing cells to improve the safety of stem-cell based therapy.
American Psychological Association (APA)
Lifantseva, Nadya& Koltsova, Anna& Krylova, Tatyana& Yakovleva, Tatyana& Poljanskaya, Galina& Gordeeva, Olga. 2011. Expression Patterns of Cancer-Testis Antigens in Human Embryonic Stem Cells and Their Cell Derivatives Indicate Lineage Tracks. Stem Cells International،Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-498749
Modern Language Association (MLA)
Lifantseva, Nadya…[et al.]. Expression Patterns of Cancer-Testis Antigens in Human Embryonic Stem Cells and Their Cell Derivatives Indicate Lineage Tracks. Stem Cells International No. 2011 (2011), pp.1-13.
https://search.emarefa.net/detail/BIM-498749
American Medical Association (AMA)
Lifantseva, Nadya& Koltsova, Anna& Krylova, Tatyana& Yakovleva, Tatyana& Poljanskaya, Galina& Gordeeva, Olga. Expression Patterns of Cancer-Testis Antigens in Human Embryonic Stem Cells and Their Cell Derivatives Indicate Lineage Tracks. Stem Cells International. 2011. Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-498749
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-498749