Oxidative Stress and Epilepsy : Literature Review
Joint Authors
Araújo, Paulo Victor Pontes
Vasconcelos, Silvânia Maria Mendes
Fonteles, Marta Maria de França
Vale, Otoni Cardoso do
Almeida, Anália Barbosa
Aguiar, Carlos Clayton Torres
Chaves, Edna Maria Camelo
Abreu, Rita Neuma Dantas Cavalcante de
Woods, David John
Macêdo, Danielle Silveira
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-08
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Backgrounds.
The production of free radicals has a role in the regulation of biological function, cellular damage, and the pathogenesis of central nervous system conditions.
Epilepsy is a highly prevalent serious brain disorder, and oxidative stress is regarded as a possible mechanism involved in epileptogenesis.
Experimental studies suggest that oxidative stress is a contributing factor to the onset and evolution of epilepsy.
Objective.
A review was conducted to investigate the link between oxidative stress and seizures, and oxidative stress and age as risk factors for epilepsy.
The role of oxidative stress in seizure induction and propagation is also discussed.
Results/Conclusions.
Oxidative stress and mitochondrial dysfunction are involved in neuronal death and seizures.
There is evidence that suggests that antioxidant therapy may reduce lesions induced by oxidative free radicals in some animal seizure models.
Studies have demonstrated that mitochondrial dysfunction is associated with chronic oxidative stress and may have an essential role in the epileptogenesis process; however, few studies have shown an established link between oxidative stress, seizures, and age.
American Psychological Association (APA)
Aguiar, Carlos Clayton Torres& Almeida, Anália Barbosa& Araújo, Paulo Victor Pontes& Abreu, Rita Neuma Dantas Cavalcante de& Chaves, Edna Maria Camelo& Vale, Otoni Cardoso do…[et al.]. 2012. Oxidative Stress and Epilepsy : Literature Review. Oxidative Medicine and Cellular Longevity،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-498752
Modern Language Association (MLA)
Aguiar, Carlos Clayton Torres…[et al.]. Oxidative Stress and Epilepsy : Literature Review. Oxidative Medicine and Cellular Longevity No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-498752
American Medical Association (AMA)
Aguiar, Carlos Clayton Torres& Almeida, Anália Barbosa& Araújo, Paulo Victor Pontes& Abreu, Rita Neuma Dantas Cavalcante de& Chaves, Edna Maria Camelo& Vale, Otoni Cardoso do…[et al.]. Oxidative Stress and Epilepsy : Literature Review. Oxidative Medicine and Cellular Longevity. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-498752
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-498752