![](/images/graphics-bg.png)
Low-Dose Tolvaptan for the Treatment of Dilutional Hyponatremia in Cirrhosis : A Case Report and Literature Review
Joint Authors
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-30
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Dilutional hyponatremia is common in decompensated cirrhosis and can be successfully treated by tolvaptan, a vasopressin V2-receptor antagonist.
Data were lacking regarding the effects of tolvaptan on cirrhotic patients with a Child-Pugh score of >10 and a serum sodium concentration of <120 mmol/L.
We report a case of forties man with a 20-year history of chronic hepatitis B presenting with yellow urine and skin.
Laboratory tests demonstrated prolonged prothrombin time, markedly elevated total bilirubin, severe hyponatremia, and a Child-Pugh score of >10.
The patient was diagnosed with dilutional hyponatremia and was treated with recommended dosage tolvaptan at first.
The serum concentration of sodium recover but the patient felt obviously thirsty.
As the dosage of tolvaptan was decreased accordingly from 15 mg to 5 mg, the patient still maintained the ideal concentration of serum sodium.
This case emphasizes that cirrhotic patient with higher Child-Pugh scores and serum sodium concentration of <120 mmol/L can be treated with lower dose of tolvaptan.
American Psychological Association (APA)
Shen, Guo& Gao, Hainv. 2014. Low-Dose Tolvaptan for the Treatment of Dilutional Hyponatremia in Cirrhosis : A Case Report and Literature Review. Case Reports in Hepatology،Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-498753
Modern Language Association (MLA)
Shen, Guo& Gao, Hainv. Low-Dose Tolvaptan for the Treatment of Dilutional Hyponatremia in Cirrhosis : A Case Report and Literature Review. Case Reports in Hepatology No. 2014 (2014), pp.1-4.
https://search.emarefa.net/detail/BIM-498753
American Medical Association (AMA)
Shen, Guo& Gao, Hainv. Low-Dose Tolvaptan for the Treatment of Dilutional Hyponatremia in Cirrhosis : A Case Report and Literature Review. Case Reports in Hepatology. 2014. Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-498753
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-498753