Epidermal Growth Factor (EGF) Treatment on Multipotential Stromal Cells (MSCs). Possible Enhancement of Therapeutic Potential of MSC
Joint Authors
Kawasaki, Haruhisa
Tamama, Kenichi
Wells, Alan
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-02-17
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Adult bone marrow multipotential stromal cells (MSCs) hold great promise in regenerative medicine and tissue engineering.
However, due to their low numbers upon harvesting, MSCs need to be expanded in vitro without biasing future differentiation for optimal utility.
In this concept paper, we focus on the potential use of epidermal growth factor (EGF), prototypal growth factor for enhancing the harvesting and/or differentiation of MSCs.
Soluble EGF was shown to augment MSC proliferation while preserving early progenitors within MSC population, and thus did not induce differentiation.
However, tethered form of EGF was shown to promote osteogenic differentiation.
Soluble EGF was also shown to increase paracrine secretions including VEGF and HGF from MSC.
Thus, soluble EGF can be used not only to expand MSC in vitro, but also to enhance paracrine secretion through drug-releasing MSC-encapsulated scaffolds in vivo.
Tethered EGF can also be utilized to direct MSC towards osteogenic lineage both in vitro and in vivo.
American Psychological Association (APA)
Tamama, Kenichi& Kawasaki, Haruhisa& Wells, Alan. 2010. Epidermal Growth Factor (EGF) Treatment on Multipotential Stromal Cells (MSCs). Possible Enhancement of Therapeutic Potential of MSC. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-498766
Modern Language Association (MLA)
Tamama, Kenichi…[et al.]. Epidermal Growth Factor (EGF) Treatment on Multipotential Stromal Cells (MSCs). Possible Enhancement of Therapeutic Potential of MSC. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-498766
American Medical Association (AMA)
Tamama, Kenichi& Kawasaki, Haruhisa& Wells, Alan. Epidermal Growth Factor (EGF) Treatment on Multipotential Stromal Cells (MSCs). Possible Enhancement of Therapeutic Potential of MSC. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-498766
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-498766