Beneficial Effects of Long-Term Administration of an Oral Formulation of Angiotensin-(1–7) in Infarcted Rats
Joint Authors
de Sousa, Frederico B.
Sinisterra, Rúben D.
Souza dos Santos, Robson Augusto
Savergnini, Silvia Quintao
Melo, Marcos B.
Marques, Fúlvia D.
Braga, Vinícius B. A.
Souza, Leandro E.
Irigoyen, Maria Claúdia C.
Ferreira, Anderson J.
Source
International Journal of Hypertension
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-09
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
In this study was evaluated the chronic cardiac effects of a formulation developed by including angiotensin(Ang)-(1–7) in hydroxypropyl β-cyclodextrin (HPβCD), in infarcted rats.
Myocardial infarction (MI) was induced by left coronary artery occlusion.
HPβCD/Ang-(1–7) was administered for 60 days (76 μg/Kg/once a day/gavage) starting immediately before infarction.
Echocardiography was utilized to evaluate usual cardiac parameters, and radial strain method was used to analyze the velocity and displacement of myocardial fibers at initial time and 15, 30, and 50 days after surgery.
Real-time PCR was utilized to evaluate the fibrotic signaling involved in the remodeling process.
Once-a-day oral HPβCD/Ang-(1–7) administration improved the cardiac function and reduced the deleterious effects induced by MI on TGF-β and collagen type I expression, as well as on the velocity and displacement of myocardial fibers.
These findings confirm cardioprotective effects of Ang-(1–7) and indicate HPβCD/Ang-(1–7) as a feasible formulation for long-term oral administration of this heptapeptide.
American Psychological Association (APA)
Marques, Fúlvia D.& Melo, Marcos B.& Souza, Leandro E.& Irigoyen, Maria Claúdia C.& Sinisterra, Rúben D.& de Sousa, Frederico B.…[et al.]. 2012. Beneficial Effects of Long-Term Administration of an Oral Formulation of Angiotensin-(1–7) in Infarcted Rats. International Journal of Hypertension،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-498775
Modern Language Association (MLA)
Marques, Fúlvia D.…[et al.]. Beneficial Effects of Long-Term Administration of an Oral Formulation of Angiotensin-(1–7) in Infarcted Rats. International Journal of Hypertension No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-498775
American Medical Association (AMA)
Marques, Fúlvia D.& Melo, Marcos B.& Souza, Leandro E.& Irigoyen, Maria Claúdia C.& Sinisterra, Rúben D.& de Sousa, Frederico B.…[et al.]. Beneficial Effects of Long-Term Administration of an Oral Formulation of Angiotensin-(1–7) in Infarcted Rats. International Journal of Hypertension. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-498775
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-498775