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Acupuncture-Evoked Response in Somatosensory and Prefrontal Cortices Predicts Immediate Pain Reduction in Carpal Tunnel Syndrome
Joint Authors
Audette, Joseph
McManus, Claire
Im, Jaehyun
Park, Kyungmo
Napadow, Vitaly
Morse, Leslie R.
Mezzacappa, Pia
Maeda, Yumi
Kim, Jieun
Cina, Stephen
Malatesta, Cristina
Kettner, Norman
Gerber, Jessica
Lee, Jeungchan
Libby, Alexandra
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-17
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The linkage between brain response to acupuncture and subsequent analgesia remains poorly understood.
Our aim was to evaluate this linkage in chronic pain patients with carpal tunnel syndrome (CTS).
Brain response to electroacupuncture (EA) was evaluated with functional MRI.
Subjects were randomized to 3 groups: (1) EA applied at local acupoints on the affected wrist (PC-7 to TW-5), (2) EA at distal acupoints (contralateral ankle, SP-6 to LV-4), and (3) sham EA at nonacupoint locations on the affected wrist.
Symptom ratings were evaluated prior to and following the scan.
Subjects in the local and distal groups reported reduced pain.
Verum EA produced greater reduction of paresthesia compared to sham.
Compared to sham EA, local EA produced greater activation in insula and S2 and greater deactivation in ipsilateral S1, while distal EA produced greater activation in S2 and deactivation in posterior cingulate cortex.
Brain response to distal EA in prefrontal cortex (PFC) and brain response to verum EA in S1, SMA, and PFC were correlated with pain reduction following stimulation.
Thus, while greater activation to verum acupuncture in these regions may predict subsequent analgesia, PFC activation may specifically mediate reduced pain when stimulating distal acupoints.
American Psychological Association (APA)
Maeda, Yumi& Kettner, Norman& Lee, Jeungchan& Kim, Jieun& Cina, Stephen& Malatesta, Cristina…[et al.]. 2013. Acupuncture-Evoked Response in Somatosensory and Prefrontal Cortices Predicts Immediate Pain Reduction in Carpal Tunnel Syndrome. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-498807
Modern Language Association (MLA)
Maeda, Yumi…[et al.]. Acupuncture-Evoked Response in Somatosensory and Prefrontal Cortices Predicts Immediate Pain Reduction in Carpal Tunnel Syndrome. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-498807
American Medical Association (AMA)
Maeda, Yumi& Kettner, Norman& Lee, Jeungchan& Kim, Jieun& Cina, Stephen& Malatesta, Cristina…[et al.]. Acupuncture-Evoked Response in Somatosensory and Prefrontal Cortices Predicts Immediate Pain Reduction in Carpal Tunnel Syndrome. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-498807
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-498807