Peroxisome Proliferator-Activated Receptor-γ-Mediated Polarization of Macrophages in Leishmania Infection
Joint Authors
Chan, Marion M.
Chen, Cui
Adapala, Nagasuresh
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-01
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Infection is the outcome of a contest between a pathogen and its host.
In the disease leishmaniasis, the causative protozoan parasites are harbored inside the macrophages.
Leishmania species adapt strategies to make the infection chronic, keeping a balance between their own and the host's defense so as to establish an environment that is favorable for survival and propagation.
Activation of peroxisome proliferator-activated receptor (PPAR) is one of the tactics used.
This ligand-activated nuclear factor curbs inflammation to protect the host from excessive injuries by setting a limit to its destructive force.
In this paper, we report the interaction of host PPARs and the pathogen for visceral leishmaniasis, Leishmania donovani, in vivo and in vitro.
PPAR expression is induced by parasitic infection.
Leishmanial activation of PPARγ promotes survival, whereas blockade of PPARγ facilitates removal of the parasite.
Thus, Leishmania parasites harness PPARγ to increase infectivity.
American Psychological Association (APA)
Chan, Marion M.& Adapala, Nagasuresh& Chen, Cui. 2012. Peroxisome Proliferator-Activated Receptor-γ-Mediated Polarization of Macrophages in Leishmania Infection. PPAR Research،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-498838
Modern Language Association (MLA)
Chan, Marion M.…[et al.]. Peroxisome Proliferator-Activated Receptor-γ-Mediated Polarization of Macrophages in Leishmania Infection. PPAR Research No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-498838
American Medical Association (AMA)
Chan, Marion M.& Adapala, Nagasuresh& Chen, Cui. Peroxisome Proliferator-Activated Receptor-γ-Mediated Polarization of Macrophages in Leishmania Infection. PPAR Research. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-498838
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-498838