In Vivo Models Used for Evaluation of Potential Antigastroduodenal Ulcer Agents
Joint Authors
Ansah, Charles
Adinortey, Michael Buenor
Galyuon, Isaac
Nyarko, Alexander
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-25
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Peptic ulcer is among the most serious gastrointestinal diseases in the world.
Several orthodox drugs are employed for the treatment of the disease.
Although these drugs are effective, they produce many adverse effects thus limiting their use.
In recent years, there has been a growing interest in alternative therapies, especially those from plants due to their perceived relative lower side effects, ease of accessibility, and affordability.
Plant medicines with ethnomedicinal use in peptic ulcer management need to be screened for their effectiveness and possible isolation of lead compounds.
This requires use of appropriate animal models of various ulcers.
The limited number of antiulcer models for drug development against gastric and duodenal ulcer studies has hindered the progress of targeted therapy in this field.
It is, therefore, necessary to review the literature on experimental models used to screen agents with potential antigastroduodenal ulcer activity and explain their biochemical basis in order to facilitate their use in the development of new preventive and curative antiulcer drugs.
Clinical trials can then be carried out on agents/drugs that show promise.
In this paper, current in vivo animal models of ulcers and the pathophysiological mechanisms underlying their induction, their limitations, as well as the challenges associated with their use have been discussed.
American Psychological Association (APA)
Adinortey, Michael Buenor& Ansah, Charles& Galyuon, Isaac& Nyarko, Alexander. 2013. In Vivo Models Used for Evaluation of Potential Antigastroduodenal Ulcer Agents. Ulcers،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-498857
Modern Language Association (MLA)
Adinortey, Michael Buenor…[et al.]. In Vivo Models Used for Evaluation of Potential Antigastroduodenal Ulcer Agents. Ulcers No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-498857
American Medical Association (AMA)
Adinortey, Michael Buenor& Ansah, Charles& Galyuon, Isaac& Nyarko, Alexander. In Vivo Models Used for Evaluation of Potential Antigastroduodenal Ulcer Agents. Ulcers. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-498857
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-498857