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The Cannabinoid Receptor Type 1 Is Essential for Mesenchymal Stem Cell Survival and Differentiation : Implications for Bone Health
Joint Authors
Gowran, Aoife
McKayed, Katey
Campbell, Veronica A.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-24
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
Significant loss of bone due to trauma, underlying metabolic disease, or lack of repair due to old age surpasses the body’s endogenous bone repair mechanisms.
Mesenchymal stem cells (MSCs) are adult stem cells which may represent an ideal cell type for use in cell-based tissue engineered bone regeneration strategies.
The body’s endocannabinoid system has been identified as a central regulator of bone metabolism.
The aim of the study was to elucidate the role of the cannabinoid receptor type 1 in the differentiation and survival of MSCs.
We show that the cannabinoid receptor type 1 has a prosurvival function during acute cell stress.
Additionally, we show that the phytocannabinoid, Δ9-Tetrahydrocannabinol, has a negative impact on MSC survival and osteogenesis.
Overall, these results show the potential for the modulation of the cannabinoid system in cell-based tissue engineered bone regeneration strategies whilst highlighting cannabis use as a potential cause for concern in the management of orthopaedic patients.
American Psychological Association (APA)
Gowran, Aoife& McKayed, Katey& Campbell, Veronica A.. 2013. The Cannabinoid Receptor Type 1 Is Essential for Mesenchymal Stem Cell Survival and Differentiation : Implications for Bone Health. Stem Cells International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-498874
Modern Language Association (MLA)
Gowran, Aoife…[et al.]. The Cannabinoid Receptor Type 1 Is Essential for Mesenchymal Stem Cell Survival and Differentiation : Implications for Bone Health. Stem Cells International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-498874
American Medical Association (AMA)
Gowran, Aoife& McKayed, Katey& Campbell, Veronica A.. The Cannabinoid Receptor Type 1 Is Essential for Mesenchymal Stem Cell Survival and Differentiation : Implications for Bone Health. Stem Cells International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-498874
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-498874