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Cytotoxicity of Environmentally Relevant Concentrations of Aluminum in Murine Thymocytes and Lymphocytes
Joint Authors
Birman, Irina
Carpenter, David O.
Kamalov, Jamal
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-27
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Pharmacy, Health & Medical Sciences
Medicine
Abstract EN
The effects of low concentrations of aluminum chloride on thymocytes and lymphocytes acutely dissociated from young mice were studied using flow cytometry with a DNA-binding dye.
We demonstrate a rapid and dose-dependent injury in murine thymocytes and lymphocytes resulting from exposure to aluminum, as indicated by an increase in the entry into the cell of the DNA-binding dye, propidium iodine.
A 60-minute exposure to 10 μM AlCl3 caused damage of about 5% of thymocytes, while 50% were injured after 10 minutes at 20 μM.
Nearly all thymocytes showed evidence of damage at 30 μM AlCl3 after only 5 minutes of incubation.
In lymphocytes, injury was observed at 15 μM AlCl3 and less than 50% of cells were injured after a 60-minute exposure to 20 μM.
Injury only rarely proceeded to rapid cell death and was associated with cell swelling.
These results suggest that aluminum has cytotoxic effects on cells of the immune system.
American Psychological Association (APA)
Kamalov, Jamal& Carpenter, David O.& Birman, Irina. 2011. Cytotoxicity of Environmentally Relevant Concentrations of Aluminum in Murine Thymocytes and Lymphocytes. Journal of Toxicology،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-498875
Modern Language Association (MLA)
Kamalov, Jamal…[et al.]. Cytotoxicity of Environmentally Relevant Concentrations of Aluminum in Murine Thymocytes and Lymphocytes. Journal of Toxicology No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-498875
American Medical Association (AMA)
Kamalov, Jamal& Carpenter, David O.& Birman, Irina. Cytotoxicity of Environmentally Relevant Concentrations of Aluminum in Murine Thymocytes and Lymphocytes. Journal of Toxicology. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-498875
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-498875