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Dietary Omega-3 Fatty Acids Do Not Change Resistance of Rat Brain or Liver Mitochondria to Ca2+ andor Prooxidants
Joint Authors
Stavrovskaya, Irina G.
Porter, Caryn L.
Marur, Vasant R.
Bird, Susan S.
Greenberg, Heather K.
Baranov, Sergei V.
Kristal, Bruce S.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-27
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Omega-3 polyunsaturated fatty acids (n-3 PUFAs) block apoptotic neuronal cell death and are strongly neuroprotective in acute and chronic neurodegeneration.
Theoretical considerations, indirect data, and consideration of parsimony lead to the hypothesis that modulation of mitochondrial pathway(s) underlies at least some of the neuroprotective effects of n-3 PUFAs.
We therefore systematically tested this hypothesis on healthy male FBFN1 rats fed for four weeks with isocaloric, 10% fat-containing diets supplemented with 1, 3, or 10% fish oil (FO).
High resolution mass spectrometric analysis confirmed expected diet-driven increases in docosahexaenoic acid (DHA, 22:6, n-3) and eicosapentaenoic acid (EPA, 20:5, n-3) in sera, liver and nonsynaptosomal brain mitochondria.
We further evaluated the resistance of brain and liver mitochondria to Ca2+ overload and prooxidants.
Under these conditions, neither mitochondrial resistance to Ca2+ overload and prooxidants nor mitochondrial physiology is altered by diet, despite the expected incorporation of DHA and EPA in mitochondrial membranes and plasma.
Collectively, the data eliminate one of the previously proposed mechanism(s) that n-3 PUFA induced augmentation of mitochondrial resistance to the oxidant/calcium-driven dysfunction.
These data furthermore allow us to define a specific series of follow-up experiments to test related hypotheses about the effect of n-3 PUFAs on brain mitochondria.
American Psychological Association (APA)
Stavrovskaya, Irina G.& Bird, Susan S.& Marur, Vasant R.& Baranov, Sergei V.& Greenberg, Heather K.& Porter, Caryn L.…[et al.]. 2012. Dietary Omega-3 Fatty Acids Do Not Change Resistance of Rat Brain or Liver Mitochondria to Ca2+ andor Prooxidants. Journal of Lipids،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-498908
Modern Language Association (MLA)
Stavrovskaya, Irina G.…[et al.]. Dietary Omega-3 Fatty Acids Do Not Change Resistance of Rat Brain or Liver Mitochondria to Ca2+ andor Prooxidants. Journal of Lipids No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-498908
American Medical Association (AMA)
Stavrovskaya, Irina G.& Bird, Susan S.& Marur, Vasant R.& Baranov, Sergei V.& Greenberg, Heather K.& Porter, Caryn L.…[et al.]. Dietary Omega-3 Fatty Acids Do Not Change Resistance of Rat Brain or Liver Mitochondria to Ca2+ andor Prooxidants. Journal of Lipids. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-498908
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-498908