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Genetic Diversity and Drug Resistance Mutations in HIV-1 from Untreated Patients in Niamey, Niger
Joint Authors
Ali Maazou, Amadou Roufaï
Aoula, Balki
Mamadou, Saïdou
Hanki, Yahayé
Diallo, Sanata
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-03
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
The objective of the study was to estimate the prevalence of transmitted resistance to antiretroviral of HIV-1 circulating in Niger.
We collected plasmas from 96 drug-naive patients followed up in the main HIV/AIDS Care Center of Niamey, the capital city of Niger.
After RNA extraction and retrotranscription to proviral DNA, nested PCR was performed to amplify PR (codons 1–99) and RT (codons 1–240) fragments for sequencing.
Sequences were analysed for phylogeny, then for resistance-associated mutations according to IAS-USA and Stanford's lists of mutations.
We characterized six HIV-1 genetic variants: CRF02-AG (56.3%), CRF30_0206 (15.6%), subtype G (15.6%), CRF06_cpx (9.4%), CRF11_cpx (2.1%), and CRF01_AE (1%).
About 8.3% of HIV strains had at least 1 resistance mutation: 4 strains with at least 1 mutation to NRTI, 5 for NNRTI, and 1 for PI, respectiveley 4.2%, 5.2%, and 1.0%.
These preliminary results gave enough information for the need of instauring HIV drug resistance national surveillance.
American Psychological Association (APA)
Mamadou, Saïdou& Hanki, Yahayé& Ali Maazou, Amadou Roufaï& Aoula, Balki& Diallo, Sanata. 2011. Genetic Diversity and Drug Resistance Mutations in HIV-1 from Untreated Patients in Niamey, Niger. ISRN Microbiology،Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-498944
Modern Language Association (MLA)
Mamadou, Saïdou…[et al.]. Genetic Diversity and Drug Resistance Mutations in HIV-1 from Untreated Patients in Niamey, Niger. ISRN Microbiology No. 2011 (2011), pp.1-4.
https://search.emarefa.net/detail/BIM-498944
American Medical Association (AMA)
Mamadou, Saïdou& Hanki, Yahayé& Ali Maazou, Amadou Roufaï& Aoula, Balki& Diallo, Sanata. Genetic Diversity and Drug Resistance Mutations in HIV-1 from Untreated Patients in Niamey, Niger. ISRN Microbiology. 2011. Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-498944
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-498944