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Transplantation of Porcine Hepatocytes Cultured with Polylactic Acid-O-Carboxymethylated Chitosan Nanoparticles Promotes Liver Regeneration in Acute Liver Failure Rats
Joint Authors
Chen, Jiahui
Guan, Weijun
Tang, Fei
Chen, Zhong
Chang, Renan
Zhu, Wencai
Cai, Hongyu
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-30
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
In this study, free porcine hepatocytes suspension (Group A), porcine hepatocytes embedded in collagen gel (Group B), porcine hepatocytes cultured with PLA-O-CMC nanoparticles and embedded in collagen gel (Group C), and PLA-O-CMC nanoparticles alone (Group D) were transplanted into peritoneal cavity of ALF rats, respectively.
The result showed that plasma HGF levels were elevated post-transplantation with a peak at 12 hr.
The rats in Group C showed highest plasma HGF levels at 2, 6, 12, 24 and 36 hr post-transplantation and lowest HGF level at 48 hr.
Plasma VEGF levels were elevated at 48 hr post-transplantation with a peak at 72 hr.
The rats in Group C showed highest plasma HGF levels at 48, 72, and 96 hr post-transplantation.
The liver functions in Group C were recovered most rapidly.
Compared with Group B, Group C had significant high liver Kiel 67 antigen labeling index (Ki-67 LI) at day 1 post-HTx (P<.05).
Ki-67 LI in groups B and C was higher than that in groups A and D at days 5 and 7 post-HTx.
In conclusion, intraperitoneal transplantation of porcine hepatocytes cultured with PLA-O-CMC nanoparticles and embedded in collagen gel can promote significantly liver regeneration in ALF rats.
American Psychological Association (APA)
Chen, Zhong& Chang, Renan& Guan, Weijun& Cai, Hongyu& Tang, Fei& Zhu, Wencai…[et al.]. 2011. Transplantation of Porcine Hepatocytes Cultured with Polylactic Acid-O-Carboxymethylated Chitosan Nanoparticles Promotes Liver Regeneration in Acute Liver Failure Rats. Journal of Drug Delivery،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-498946
Modern Language Association (MLA)
Chen, Zhong…[et al.]. Transplantation of Porcine Hepatocytes Cultured with Polylactic Acid-O-Carboxymethylated Chitosan Nanoparticles Promotes Liver Regeneration in Acute Liver Failure Rats. Journal of Drug Delivery No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-498946
American Medical Association (AMA)
Chen, Zhong& Chang, Renan& Guan, Weijun& Cai, Hongyu& Tang, Fei& Zhu, Wencai…[et al.]. Transplantation of Porcine Hepatocytes Cultured with Polylactic Acid-O-Carboxymethylated Chitosan Nanoparticles Promotes Liver Regeneration in Acute Liver Failure Rats. Journal of Drug Delivery. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-498946
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-498946