Advances in Murine Models of Diabetic Nephropathy
Joint Authors
Kong, Li-li
Yuan, Hang
Sun, Jing
Cui, Wen-peng
Wu, Hao
Miao, Li-ning
Luo, Ping
Zhou, Wen-hua
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-13
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Diabetic nephropathy (DN) is one of the microvascular complications of both type 1 and type 2 diabetes, which is also associated with a poor life expectancy of diabetic patients.
However, the pathogenesis of DN is still unclear.
Thus, it is of great use to establish appropriate animal models of DN for doing research on pathogenesis and developing novel therapeutic strategies.
Although a large number of murine models of DN including artificially induced, spontaneous, and genetically engineered (knockout and transgenic) animal models have been developed, none of them develops renal changes sufficiently reflecting those seen in humans.
Here we review the identified murine models of DN from the aspects of genetic background, type of diabetes, method of induction, gene deficiency, animal age and gender, kidney histopathology, and phenotypic alterations in the hope of enhancing our comprehension of genetic susceptibility and molecular mechanisms responsible for this disease and providing new clues as to how to choose appropriate animal models of DN.
American Psychological Association (APA)
Kong, Li-li& Wu, Hao& Cui, Wen-peng& Zhou, Wen-hua& Luo, Ping& Sun, Jing…[et al.]. 2013. Advances in Murine Models of Diabetic Nephropathy. Journal of Diabetes Research،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-498949
Modern Language Association (MLA)
Kong, Li-li…[et al.]. Advances in Murine Models of Diabetic Nephropathy. Journal of Diabetes Research No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-498949
American Medical Association (AMA)
Kong, Li-li& Wu, Hao& Cui, Wen-peng& Zhou, Wen-hua& Luo, Ping& Sun, Jing…[et al.]. Advances in Murine Models of Diabetic Nephropathy. Journal of Diabetes Research. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-498949
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-498949