Therapeutic Potential of MicroRNA : A New Target to Treat Intrahepatic Portal Hypertension?
Joint Authors
Guo, Can-Jie
Ma, Xiong
Bian, Zhao-Lian
Pan, Qin
Qiao, Yu-Qi
Zhong, Wei
Hua, Jing
Shen, Lei
Li, Hai
Xiong, Hua
Sheng, Li
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-09
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Intrahepatic portal hypertension accounts for most of the morbidity and mortality encountered in patients with liver cirrhosis, due to increased portal inflow and intrahepatic vascular resistance.
Most treatments have focused only on portal inflow or vascular resistance.
However, miRNA multitarget regulation therapy may potentially intervene in these two processes for therapeutic benefit in cirrhosis and portal hypertension.
This review presents an overview of the most recent knowledge of and future possibilities for the use of miRNA therapy.
The benefits of this therapeutic modality—which is poorly applied in the clinical setting—are still uncertain.
Increasing the knowledge and current understanding of the roles of miRNAs in the development of intrahepatic portal hypertension and hepatic stellate cells (HSCs) functions, as well as their potential as novel drug targets, is critical.
American Psychological Association (APA)
Guo, Can-Jie& Pan, Qin& Xiong, Hua& Qiao, Yu-Qi& Bian, Zhao-Lian& Zhong, Wei…[et al.]. 2014. Therapeutic Potential of MicroRNA : A New Target to Treat Intrahepatic Portal Hypertension?. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-498967
Modern Language Association (MLA)
Guo, Can-Jie…[et al.]. Therapeutic Potential of MicroRNA : A New Target to Treat Intrahepatic Portal Hypertension?. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-498967
American Medical Association (AMA)
Guo, Can-Jie& Pan, Qin& Xiong, Hua& Qiao, Yu-Qi& Bian, Zhao-Lian& Zhong, Wei…[et al.]. Therapeutic Potential of MicroRNA : A New Target to Treat Intrahepatic Portal Hypertension?. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-498967
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-498967