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Genetic Markers Used for Risk Stratification in Multiple Myeloma
Joint Authors
Braggio, Esteban
Segges, Priscilla
Source
Genetics Research International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-13
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
While no specific genetic markers are required in the diagnosis of multiple myeloma (MM), multiple genetic abnormalities and gene signatures are used in disease prognostication and risk stratification.
This is particularly important for the adequate identification of the high-risk MM group, which does not benefit from any of the current therapies, and novel approaches need to be proposed.
Fluorescence in situ hybridization (FISH) has been employed for establishing risk-based stratification and still remains the most used genetic technique in the clinical routine.
The incorporation of gene expression profiling (GEP) in the study of MM has shown to be a very powerful test in the patient stratification, but its incorporation in clinical routine depends on some technical and logistic resolutions.
Thus, FISH still remains the gold standard test for detecting genomic abnormalities and outcome discrimination in MM.
American Psychological Association (APA)
Segges, Priscilla& Braggio, Esteban. 2011. Genetic Markers Used for Risk Stratification in Multiple Myeloma. Genetics Research International،Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-498987
Modern Language Association (MLA)
Segges, Priscilla& Braggio, Esteban. Genetic Markers Used for Risk Stratification in Multiple Myeloma. Genetics Research International No. 2011 (2011), pp.1-4.
https://search.emarefa.net/detail/BIM-498987
American Medical Association (AMA)
Segges, Priscilla& Braggio, Esteban. Genetic Markers Used for Risk Stratification in Multiple Myeloma. Genetics Research International. 2011. Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-498987
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-498987