Low-Dose Cyclophosphamide Synergizes with Dendritic Cell-Based Immunotherapy in Antitumor Activity
Joint Authors
Hegmans, Joost P. J. J.
Hoogsteden, Henk C.
Hendriks, Rudi W.
Lambers, Margaretha E. H.
Veltman, Joris D.
van Nimwegen, Menno
Aerts, Joachim G. J. V.
de Jong, Sanne
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-05-23
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Clinical immunotherapy trials like dendritic cell-based vaccinations are hampered by the tumor's offensive repertoire that suppresses the incoming effector cells.
Regulatory T cells are instrumental in suppressing the function of cytotoxic T cells.
We studied the effect of low-dose cyclophosphamide on the suppressive function of regulatory T cells and investigated if the success rate of dendritic cell immunotherapy could be improved.
For this, mesothelioma tumor-bearing mice were treated with dendritic cell-based immunotherapy alone or in combination with low-dose of cyclophosphamide.
Proportions of regulatory T cells and the cytotoxic T cell functions at different stages of disease were analyzed.
We found that low-dose cyclophosphamide induced beneficial immunomodulatory effects by preventing the induction of Tregs, and as a consequence, cytotoxic T cell function was no longer affected.
Addition of cyclophosphamide improved immunotherapy leading to an increased median and overall survival.
Future studies are needed to address the usefulness of this combination treatment for mesothelioma patients.
American Psychological Association (APA)
Veltman, Joris D.& Lambers, Margaretha E. H.& van Nimwegen, Menno& de Jong, Sanne& Hendriks, Rudi W.& Hoogsteden, Henk C.…[et al.]. 2010. Low-Dose Cyclophosphamide Synergizes with Dendritic Cell-Based Immunotherapy in Antitumor Activity. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-499036
Modern Language Association (MLA)
Veltman, Joris D.…[et al.]. Low-Dose Cyclophosphamide Synergizes with Dendritic Cell-Based Immunotherapy in Antitumor Activity. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-499036
American Medical Association (AMA)
Veltman, Joris D.& Lambers, Margaretha E. H.& van Nimwegen, Menno& de Jong, Sanne& Hendriks, Rudi W.& Hoogsteden, Henk C.…[et al.]. Low-Dose Cyclophosphamide Synergizes with Dendritic Cell-Based Immunotherapy in Antitumor Activity. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-499036
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499036