Gene Expression Differences between Enriched Normal and Chronic Myelogenous Leukemia Quiescent StemProgenitor Cells and Correlations with Biological Abnormalities
Joint Authors
Affer, M.
Liu, C.
Mo, Q.
Viale, A.
Lambek, C. L.
Olshen, A. B.
Clarkson, B. D.
Marr, T. G.
Dao, S.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-25, 25 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-02-23
Country of Publication
Egypt
No. of Pages
25
Main Subjects
Abstract EN
In comparing gene expression of normal and CML CD34+ quiescent (G0) cell, 292 genes were downregulated and 192 genes upregulated in the CML/G0 Cells.
The differentially expressed genes were grouped according to their reported functions, and correlations were sought with biological differences previously observed between the same groups.
The most relevant findings include the following.
(i) CML G0 cells are in a more advanced stage of development and more poised to proliferate than normal G0 cells.
(ii) When CML G0 cells are stimulated to proliferate, they differentiate and mature more rapidly than normal counterpart.
(iii) Whereas normal G0 cells form only granulocyte/monocyte colonies when stimulated by cytokines, CML G0 cells form a combination of the above and erythroid clusters and colonies.
(iv) Prominin-1 is the gene most downregulated in CML G0 cells, and this appears to be associated with the spontaneous formation of erythroid colonies by CML progenitors without EPO.
American Psychological Association (APA)
Affer, M.& Dao, S.& Liu, C.& Olshen, A. B.& Mo, Q.& Viale, A.…[et al.]. 2011. Gene Expression Differences between Enriched Normal and Chronic Myelogenous Leukemia Quiescent StemProgenitor Cells and Correlations with Biological Abnormalities. Journal of Oncology،Vol. 2011, no. 2011, pp.1-25.
https://search.emarefa.net/detail/BIM-499052
Modern Language Association (MLA)
Affer, M.…[et al.]. Gene Expression Differences between Enriched Normal and Chronic Myelogenous Leukemia Quiescent StemProgenitor Cells and Correlations with Biological Abnormalities. Journal of Oncology No. 2011 (2011), pp.1-25.
https://search.emarefa.net/detail/BIM-499052
American Medical Association (AMA)
Affer, M.& Dao, S.& Liu, C.& Olshen, A. B.& Mo, Q.& Viale, A.…[et al.]. Gene Expression Differences between Enriched Normal and Chronic Myelogenous Leukemia Quiescent StemProgenitor Cells and Correlations with Biological Abnormalities. Journal of Oncology. 2011. Vol. 2011, no. 2011, pp.1-25.
https://search.emarefa.net/detail/BIM-499052
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499052