Cutaneous Inflammatory Malignant Fibrous Histiocytoma Presenting with a Leukemoid Reaction : A Case Report and Review of the Literature
Joint Authors
Frieri, Marianne
Hurtado-Cordovi, Jorge M.
Freedman, Lester
Avezbakiyev, Boris
Gebre, Wondwoosen
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-10
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Malignant fibrous histiocytoma (MFH) is the most common sarcoma found in adults.
We discuss a case of inflammatory MFH of dermal/epidermal origin presenting with a severe leukemoid reaction (LR).
A 60 years old white male presented to hematology/oncology clinic complaining of mild shortness of breath on exertion.
Past medical history was remarkable for removal of a left upper extremity necrotic mass 4.4 × 3 × 3 cm.
Microscopy of the specimen showed clear surgical margin, and tumor cells restricted to the dermis without lymphovascular invasion.
Immunohistochemestry was positive for CD 68 and CD 99.
Chest x-ray was negative for metastatic disease.
White blood cell count was 109.4 k/mm3 with 24 k/mm3 band neutrophils, and absolute neutrophil count of 69 k/mm3.
CT scan of the thorax revealed numerous bilateral pulmonary nodules suspicious for metastasis.
Based on these findings patient was diagnosed with metastatic cutaneous IMFH associated with a LR.
Following review of medical literature, this appears to be the first reported case of inflammatory cutaneous MFH associated with LR.
This histological variant is rare, and carries a poor prognosis.
Thus, we would like to emphasize the need for investigating alternative therapies capable of improving the survival of these patients.
American Psychological Association (APA)
Hurtado-Cordovi, Jorge M.& Avezbakiyev, Boris& Frieri, Marianne& Freedman, Lester& Gebre, Wondwoosen. 2012. Cutaneous Inflammatory Malignant Fibrous Histiocytoma Presenting with a Leukemoid Reaction : A Case Report and Review of the Literature. Case Reports in Medicine،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-499055
Modern Language Association (MLA)
Hurtado-Cordovi, Jorge M.…[et al.]. Cutaneous Inflammatory Malignant Fibrous Histiocytoma Presenting with a Leukemoid Reaction : A Case Report and Review of the Literature. Case Reports in Medicine No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-499055
American Medical Association (AMA)
Hurtado-Cordovi, Jorge M.& Avezbakiyev, Boris& Frieri, Marianne& Freedman, Lester& Gebre, Wondwoosen. Cutaneous Inflammatory Malignant Fibrous Histiocytoma Presenting with a Leukemoid Reaction : A Case Report and Review of the Literature. Case Reports in Medicine. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-499055
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499055