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Possible Association of Etanercept, Venous Thrombosis, and Induction of Antiphospholipid Syndrome
Joint Authors
Brandau, Anthony
Virupannavar, Shanti
Laird-Fick, Heather S.
Guggenheim, Carla
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-15
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Tumor necrosis factor α (TNF α) inhibitors are commonly used for treatment of aggressive rheumatoid arthritis and other rheumatic diseases.
Etanercept is one of the medications approved for treatment of rheumatoid arthritis.
Though many studies have documented the safety and efficacy of these medications, evidence for adverse effects is emerging including cancer, infections, and cardiovascular disease.
There have been studies showing that these medications induce autoantibody production, including antinuclear antibodies and anti-dsDNA antibodies.
Limited data exists, however, regarding induction of antiphospholipid antibodies (APLs) by TNF α inhibitors, including anticardiolipin antibodies (ACLs), lupus anticoagulant (LAC), and anti-β2-glycoprotein I (anti-β2 GPI), or an association between antibody development and clinical manifestations.
In this case series, we describe five patients who developed venous thromboembolism (VTE) and APLs while receiving etanercept therapy.
All five of our patients met the criteria for diagnosis of APS after receiving etanercept.
Our case series supports the association between etanercept, APLs, and VTE.
We believe that testing for APLs prior to initiation of anti-TNF therapy is reasonable, given this relationship and the risks associated with VTE.
American Psychological Association (APA)
Virupannavar, Shanti& Brandau, Anthony& Guggenheim, Carla& Laird-Fick, Heather S.. 2014. Possible Association of Etanercept, Venous Thrombosis, and Induction of Antiphospholipid Syndrome. Case Reports in Rheumatology،Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-499086
Modern Language Association (MLA)
Virupannavar, Shanti…[et al.]. Possible Association of Etanercept, Venous Thrombosis, and Induction of Antiphospholipid Syndrome. Case Reports in Rheumatology No. 2014 (2014), pp.1-4.
https://search.emarefa.net/detail/BIM-499086
American Medical Association (AMA)
Virupannavar, Shanti& Brandau, Anthony& Guggenheim, Carla& Laird-Fick, Heather S.. Possible Association of Etanercept, Venous Thrombosis, and Induction of Antiphospholipid Syndrome. Case Reports in Rheumatology. 2014. Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-499086
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499086