Modified Titanium Implant as a Gateway to the Human Body : The Implant Mediated Drug Delivery System
Joint Authors
Cho, Joo-Youn
Lee, Shin-Jae
Park, Young-Seok
Hwang, Chee Il
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-22
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The aim of this study was to investigate the efficacy of a proposed new implant mediated drug delivery system (IMDDS) in rabbits.
The drug delivery system is applied through a modified titanium implant that is configured to be implanted into bone.
The implant is hollow and has multiple microholes that can continuously deliver therapeutic agents into the systematic body.
To examine the efficacy and feasibility of the IMDDS, we investigated the pharmacokinetic behavior of dexamethasone in plasma after a single dose was delivered via the modified implant placed in the rabbit tibia.
After measuring the plasma concentration, the areas under the curve showed that the IMDDS provided a sustained release for a relatively long period.
The result suggests that the IMDDS can deliver a sustained release of certain drug components with a high bioavailability.
Accordingly, the IMDDS may provide the basis for a novel approach to treating patients with chronic diseases.
American Psychological Association (APA)
Park, Young-Seok& Cho, Joo-Youn& Lee, Shin-Jae& Hwang, Chee Il. 2014. Modified Titanium Implant as a Gateway to the Human Body : The Implant Mediated Drug Delivery System. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-499110
Modern Language Association (MLA)
Park, Young-Seok…[et al.]. Modified Titanium Implant as a Gateway to the Human Body : The Implant Mediated Drug Delivery System. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-499110
American Medical Association (AMA)
Park, Young-Seok& Cho, Joo-Youn& Lee, Shin-Jae& Hwang, Chee Il. Modified Titanium Implant as a Gateway to the Human Body : The Implant Mediated Drug Delivery System. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-499110
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499110