A New Type of Biphasic Calcium Phosphate Cement as a Gentamicin Carrier for Osteomyelitis
Joint Authors
Chen, Yu-Chun
Lin, Feng-Huei
Su, Wen-Yu
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-09
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Osteomyelitis therapy is a long-term and inconvenient procedure for a patient.
Antibiotic-loaded bone cements are both a complementary and alternative treatment option to intravenous antibiotic therapy for the treatment of osteomyelitis.
In the current study, the biphasic calcium phosphate cement (CPC), called α-TCP/HAP (α-tricalcium phosphate/hydroxyapatite) biphasic cement, was prepared as an antibiotics carrier for osteomyelitis.
The developed biphasic cement with a microstructure of α-TCP surrounding the HAP has a fast setting time which will fulfill the clinical demand.
The X-ray diffraction and Fourier transform infrared spectrometry analyses showed the final phase to be HAP, the basic bone mineral, after setting for a period of time.
Scanning electron microscopy revealed a porous structure with particle sizes of a few micrometers.
The addition of gentamicin in α-TCP/HAP would delay the transition of α-TCP but would not change the final-phase HAP.
The gentamicin-loaded α-TCP/HAP supplies high doses of the antibiotic during the initial 24 hours when they are soaked in phosphate buffer solution (PBS).
Thereafter, a slower drug release is produced, supplying minimum inhibitory concentration until the end of the experiment (30 days).
Studies of growth inhibition of Staphylococcus aureus and Pseudomonas aeruginosa in culture indicated that gentamicin released after 30 days from α-TCP/HAP biphasic cement retained antibacterial activity.
American Psychological Association (APA)
Su, Wen-Yu& Chen, Yu-Chun& Lin, Feng-Huei. 2013. A New Type of Biphasic Calcium Phosphate Cement as a Gentamicin Carrier for Osteomyelitis. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-499112
Modern Language Association (MLA)
Su, Wen-Yu…[et al.]. A New Type of Biphasic Calcium Phosphate Cement as a Gentamicin Carrier for Osteomyelitis. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-499112
American Medical Association (AMA)
Su, Wen-Yu& Chen, Yu-Chun& Lin, Feng-Huei. A New Type of Biphasic Calcium Phosphate Cement as a Gentamicin Carrier for Osteomyelitis. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-499112
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499112