![](/images/graphics-bg.png)
In Vitro Chronic Administration of ERbeta Selective Ligands and Prostate Cancer Cell Growth : Hypotheses on the Selective Role of 3beta-Adiol in AR-Positive RV1 Cells
Joint Authors
Colciago, Alessandra
Negri-Cesi, Paola
Montagnani-Marelli, Marina
Ruscica, Massimiliano
Magni, Paolo
Festuccia, Claudio
Motta, Marcella
Piccolella, Margherita
Mornati, Ornella
Eberini, Ivano
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-29
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Prostate cancer (PC) progression from androgen-dependent (AD) to castration-resistant (CR) disease is a process caused by modifications of different signal transduction pathways within tumor microenvironment.
Reducing cell proliferation, estrogen receptor beta (ERbeta) is emerging as a potential target in PC chemoprevention.
Among the known selective ERbeta ligands, 3beta-Adiol, the endogenous ligand in the prostate, has been proved to counteract PC progression.
This study compares the effects of chronic exposure (1–12 weeks) to different ERbeta selective ligands (DPN, 8beta-VE2, 3beta-Adiol) on proliferation of human androgen-responsive CWR22Rv1 cells, representing an intermediate phenotype between the AD- and CR-PC.
3beta-Adiol (10 nM) is the sole ligand decreasing cell proliferation and increasing p21 levels.
In vitro transcriptional activity assays were performed to elucidate different behavior between 3beta-Adiol and the other ligands; in these experiments the endogenous and the main ERbeta subtype activation were considered.
It is concluded that ERbeta activation has positive effects also in androgen-responsive PC.
The underlying mechanisms are still to be clarified and may include the interplay among different ERbeta subtypes and the specific PC microenvironment.
ERbeta agonists might be useful in counteracting PC progression, although the final outcome may depend upon the molecular pattern specific to each PC lesion.
American Psychological Association (APA)
Colciago, Alessandra& Ruscica, Massimiliano& Mornati, Ornella& Piccolella, Margherita& Montagnani-Marelli, Marina& Eberini, Ivano…[et al.]. 2014. In Vitro Chronic Administration of ERbeta Selective Ligands and Prostate Cancer Cell Growth : Hypotheses on the Selective Role of 3beta-Adiol in AR-Positive RV1 Cells. BioMed Research International،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-499123
Modern Language Association (MLA)
Colciago, Alessandra…[et al.]. In Vitro Chronic Administration of ERbeta Selective Ligands and Prostate Cancer Cell Growth : Hypotheses on the Selective Role of 3beta-Adiol in AR-Positive RV1 Cells. BioMed Research International No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-499123
American Medical Association (AMA)
Colciago, Alessandra& Ruscica, Massimiliano& Mornati, Ornella& Piccolella, Margherita& Montagnani-Marelli, Marina& Eberini, Ivano…[et al.]. In Vitro Chronic Administration of ERbeta Selective Ligands and Prostate Cancer Cell Growth : Hypotheses on the Selective Role of 3beta-Adiol in AR-Positive RV1 Cells. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-499123
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499123