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Generation and Analysis of Large-Scale Data-Driven Mycobacterium tuberculosis Functional Networks for Drug Target Identification
Joint Authors
Mazandu, Gaston K.
Mulder, Nicola J.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-29
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Technological developments in large-scale biological experiments, coupled with bioinformatics tools, have opened the doors to computational approaches for the global analysis of whole genomes.
This has provided the opportunity to look at genes within their context in the cell.
The integration of vast amounts of data generated by these technologies provides a strategy for identifying potential drug targets within microbial pathogens, the causative agents of infectious diseases.
As proteins are druggable targets, functional interaction networks between proteins are used to identify proteins essential to the survival, growth, and virulence of these microbial pathogens.
Here we have integrated functional genomics data to generate functional interaction networks between Mycobacterium tuberculosis proteins and carried out computational analyses to dissect the functional interaction network produced for identifying drug targets using network topological properties.
This study has provided the opportunity to expand the range of potential drug targets and to move towards optimal target-based strategies.
American Psychological Association (APA)
Mazandu, Gaston K.& Mulder, Nicola J.. 2011. Generation and Analysis of Large-Scale Data-Driven Mycobacterium tuberculosis Functional Networks for Drug Target Identification. Advances in Bioinformatics،Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-499125
Modern Language Association (MLA)
Mazandu, Gaston K.& Mulder, Nicola J.. Generation and Analysis of Large-Scale Data-Driven Mycobacterium tuberculosis Functional Networks for Drug Target Identification. Advances in Bioinformatics No. 2011 (2011), pp.1-14.
https://search.emarefa.net/detail/BIM-499125
American Medical Association (AMA)
Mazandu, Gaston K.& Mulder, Nicola J.. Generation and Analysis of Large-Scale Data-Driven Mycobacterium tuberculosis Functional Networks for Drug Target Identification. Advances in Bioinformatics. 2011. Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-499125
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-499125